A Clinical Atlas of 101 Common Skin Diseases

Amyloidosis

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A condition in which deposits of a fibrillary protein (amyloid) appear in the skin as macules, papules, and nodules consequent to the effects of local factors, or as patches (which may be purpuric), plaques, nodules, and tumors as a result of a systemic disease like myeloma.

A Clinical Atlas of 101 Common Skin Diseases

Amyloidosis

A condition in which deposits of a fibrillary protein (amyloid) appear in the skin as macules, papules, and nodules consequent to the effects of local factors, or as patches (which may be purpuric), plaques, nodules, and tumors as a result of a syst…

Histologic Diagnosis of Inflammatory Skin Diseases

Macular and papular (lichenoid) amyloidosis-Cutaneous solely

…ules and papules Course Protracted Variations clinical Papular amyloidosis (lichenoid amyloidosis) represents macular amyloidosis on which lichen simplex chronicus has been imposed. Differential diagnosis clinical A similar rippled pattern is seen in…

Differential Diagnosis in Dermatopathology

Lichen amyloidosis vs. Colloid milium

A condition in which deposits of a fibrillary protein (amyloid) appear in the skin as macules, papules, and nodules consequent to the effects of local factors, or as patches (which may be purpuric), plaques, nodules, and tumors as a result of a syst…

Differential Diagnosis in Dermatopathology

Discussions

…is likely that fibrocytes are responsible for the formation of amyloid in lichen amyloidosis and of colloid in colloid milium. Because of the highly characteristic attributes histopathologic conditions, just listed, specialized stains need not be per…

Dermatology Practical & Conceptual

Notalgia paresthetica: the unreachable itch

…dermal melanophages [2,3,6]. Some studies show no evidence of amyloid deposition in NP [2,6], while others do report sparse amyloid detected in dermal papillae [3,10]. This type of cutaneous amyloid is the result of damage to keratinocytes from chro…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…les in the papillary dermis + 11.3.1C + 11.3.1D = Amyloidosis, macular  The absence of any sign of lichen simplex chronicus indicates that this is a macular, rather than a papular, expression of amyloidosis. Scratching is thought to kill…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

Lichen amyloidosis Colloid milium 1. Surface scalloped 1. Surface domed 2. Foci of compact orthokeratosis associated with epidermal hyperplasia overlie globules of amyloid in the papillary dermis 2. Thinned epidermis with loss of the normal un…

Dermatology Practical & Conceptual

Widespread pruritic papules on the trunk and extremities

…and hypodermis were normal. A diagnosis of generalized lichen amyloidosis, based on clinical and histopathological findings, was made. Lichen amyloidosis (LA) is a form of primary cutaneous amyloidosis without systemic involvement, characterized by…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Hyalin?

…:480-85. “Amyloid-hyaline-colloid deposition. Disorder: Amyloidoses Familial amyloidotic neuropathy ß2-Microglobulin amyloid Colloid milium Hyalinosis cutis et mucosae Porphyria Gout (tophi) Waldenstrom’s macroglobulinemia (storage papul…