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Therapeutic Strategies in Dermatology

Palmar and Plantar Keratoderma: Overview

Overview Palmoplantar keratodermas (PPK) can occur as a primary, inherited disorder of the volar surfaces, or as part of a generalized disorder, such as psoriasis, cutaneous T-cell lymphoma, or ichthyosis. Discussion of treatment here is limited to…

Therapeutic Strategies in Dermatology

Ichthyoses/Disorders of Cornification: Overview

Overview Ichthyosis results from abnormal retention and/or production of the stratum corneum layer of the epidermis. Acquired ichthyosis can be a cutaneous manifestation of an underlying disease (e.g., malignant neoplasm, metabolic disorder, malabso…

Therapeutic Strategies in Dermatology

Chondrodermatitis Nodularis Helicis: Key Points

Key Points Chondrodermatitis nodularis helicis (CNH) is an uncommon, strikingly painful lesion on the helix or antihelix of the ear, which often appears as a crusted ulceration mimicking a cutaneous malignancy. Diagnosis may be made by clinical exa…

A Clinical Atlas of 101 Common Skin Diseases

Pyogenic Granuloma

A red, often ulcerated, boggy papule that represents a hyperplasia of small cutaneous vessels which are “fed” by an arteriole in the subcutaneous fat, the lesion resulting consistently from external trauma, usually in the form of a punct…

A Clinical Atlas of 101 Common Skin Diseases

Dermatomyositis

An inflammatory disease of children and adults that tends to involve skin and skeletal muscle mostly, the findings in the skin being patches with the color of heliotrope, especially in the periocular region. The disease manifests itself as poikilode…

A Clinical Atlas of 101 Common Skin Diseases

Cysts and Cystic Hamartomas

Papules, nodules, and tumors that, on gross examination, are usually skin colored and, on histopathologic examination, consist of an epithelium-lined sac that contains fluid, cells, or both in the case of true cysts and of cysts that are associated…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Subcutaneous Fat: Panniculitis

See Fig. 5.385 A-C. Figure 5.385 Patterns of panniculitis. A. Septal mostly. B. Lobular mostly. C. Septal and lobular “equally.” At scanning magnification, the normal subcutaneous fat is seen to be segregated by struts of fibrous tiss…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.63.1A: Perivascular dermatitis, interface, vacuolar + 10.63.1B: Smudged appearance of the dermoepidermal junction, focally thinned epidermis, and plentiful mucin throughout the dermis = Lupus erythematosus, discoid ┬áThe presence…

Histologic Diagnosis of Inflammatory Skin Diseases

Degos’ disease (malignant atrophic papulosis)

Degos’ disease (malignant atrophic papulosis) Synonyms Degos’ syndrome Malignant atrophic papulosis Papulosis atrophicans maligna Koehlmeier-Degos syndrome Thromboangiitis cutaneointestinalis disseminata Fatal cutaneointestinal syndrome…

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