Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Vesicular Dermatitis

See Fig. 5.239 A-C. Figure 5.239 A-C. Patterns of vesiculation: intraepidermal, subepidermal, and intra- and subepidermal. “Blister” and “vesiculobullous” are terms generic for lesions of the skin that usually are elevated…

Histologic Diagnosis of Inflammatory Skin Diseases

Extraction of the Specimen

If the punch technique is employed to remove tissue from an inflammatory disease of the skin, it should be done correctly. The diameter of the punch (not less than 3 mm) should be adequate to sample the pathologic process, and, nearly always, the in…

Histologic Diagnosis of Inflammatory Skin Diseases

Fixation of the Specimen

The usual fixative for skin specimens is 10% buffered formalin. The amount of formalin should be approximately 20 times by volume that of the specimen. A surgeon, not an assistant, should be responsible for ensuring that the specimen is prevented fr…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Follicular Degeneration Syndrome?

…sheath appear to be separated from one another, but that is an artifact produced by the blade of a microtome. It is this artifact of processing that Sperling seems to have misconstrued as the cause of follicular degeneration syndrome. Although &#8220…

Histologic Diagnosis of Inflammatory Skin Diseases

Melanocytes

Melanocytes synthesize melanin. From precursors in the neural crest, melanocytes migrate normally to the epidermis, the bulb of hair follicles, epithelia of various mucous membranes, leptomeninges, inner ear, and a few other tissues (Fig. 1.61). Pri…

Histologic Diagnosis of Inflammatory Skin Diseases

Scar

Scar Synonyms Cicatrix Presentation stereotypical Age and sex Any age and both sexes Distribution of lesions Usually localized, but sometimes widespread Configuration of lesions Linear, as in a surgical wound Round, as a consequence of an ulcer ind…

Histologic Diagnosis of Inflammatory Skin Diseases

Langerhans’ Cells

Langerhans’ cells, named for Paul Langerhans who, while a medical student in Berlin in 1868, was the first to describe them, are dendritic cells that reside just above the middle of the spinous zone of the epidermis. They make their appearance…

Histologic Diagnosis of Inflammatory Skin Diseases

Lichen planus

Lichen planus Synonyms Lichen ruber planus Lichen ruber Presentation stereotypical Age and sex More common in women, especially young and middle-aged adults Distribution of lesions Flexor surface of forearms and wrists, but no site is exempt. Occu…