Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Vesicular Dermatitis

…is (and in a proliferation of keratocytes) is a space created artifactually in the course of preparation of a section of tissue technically; it is empty (Fig. 5.274 A&B), unlike a blister, no matter how minuscule that fluid-filled lesion may be (…

Histologic Diagnosis of Inflammatory Skin Diseases

Extraction of the Specimen

…. The result is such distortion of cells (“crush” artifact) that sections from such a specimen are unreadable histopathologically (Fig. 4.3). That is particularly true of sections in which the differential diagnosis is vexing even under o…

Histologic Diagnosis of Inflammatory Skin Diseases

Fixation of the Specimen

…nd the cap of the bottle; that mishap results in severe crush artifact that distorts findings histopathologic beyond recognition. Once it has been verified that the specimen is submerged, the cap of the specimen bottle must be tightened firmly to pre…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Follicular Degeneration Syndrome?

…heath appear to be separated from one another, but that is an artifact produced by the blade of a microtome. It is this artifact of processing that Sperling seems to have misconstrued as the cause of follicular degeneration syndrome. Although “…

Histologic Diagnosis of Inflammatory Skin Diseases

Melanocytes

…ere named “clear cells” by Masson, actually is an artifact of fixation during which cytoplasm shrinks and becomes concentrated around the nucleus, thereby creating a lacuna. In fact, melanocytes are not clear cells; they possess abundant…

Histologic Diagnosis of Inflammatory Skin Diseases

Scar

…equence, a subepidermal cleft comes into being. A cleft is an artifact, a space. When, however, serum finds its way into such a subepidermal space, a subepidermal blister results, and that happens episodically above some scars. In most instances, a s…

Histologic Diagnosis of Inflammatory Skin Diseases

Langerhans’ Cells

…fact, the space that surrounds Langerhans” cells is an artifact caused by shrinkage during processing, just as is the case for melanocytes. The most reliable means for identification of Langerhans” cells is electron microscopy, which rev…