Search Results for: artifact

Histologic Diagnosis of Inflammatory Skin Diseases

Extraction of the Specimen

…ezing the specimen with forceps as it is lifted from its socket. The result is such distortion of cells (“crush” artifact) that sections from such a specimen are unreadable histopathologically (Fig. 4.3). That is particularly true of…

Histologic Diagnosis of Inflammatory Skin Diseases

Fixation of the Specimen

…specimen is prevented from becoming lodged between the glass and the cap of the bottle; that mishap results in severe crush artifact that distorts findings histopathologic beyond recognition. Once it has been verified that the specimen is…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Follicular Degeneration Syndrome?

…in sections prepared routinely, some corneocytes of the inner sheath appear to be separated from one another, but that is an artifact produced by the blade of a microtome. It is this artifact of processing that Sperling seems to have misconstrued as…

Histologic Diagnosis of Inflammatory Skin Diseases

Melanocytes

…. The space characteristic of melanocytes, and for which they were named “clear cells” by Masson, actually is an artifact of fixation during which cytoplasm shrinks and becomes concentrated around the nucleus, thereby creating a lacuna….

Histologic Diagnosis of Inflammatory Skin Diseases

Scar

…them. Sometimes those vacuoles become confluent, and, as a consequence, a subepidermal cleft comes into being. A cleft is an artifact, a space. When, however, serum finds its way into such a subepidermal space, a subepidermal blister results, and…

Histologic Diagnosis of Inflammatory Skin Diseases

Langerhans’ Cells

…rpreted incorrectly as “high-level melanocytes.” In fact, the space that surrounds Langerhans” cells is an artifact caused by shrinkage during processing, just as is the case for melanocytes. The most reliable means for…

On the nature of thought processes and their relationship to the accumulation of knowledge, Part XVI-The process of making a diagnosis

On the nature of thought processes and their relationship to the accumulation of knowledge, Part XVI-The process of making a diagnosis

…more visible (perhaps with a monoclonal antibody and/or a chromogen). Even when we look histologically at structure, we see artifact induced by us-the process of biopsy wrenches the tissue from the rest of the body thereby severing its ability to…