Search Results for: basement membrane

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Therapeutic Strategies in Dermatology

Bullous Pemphigoid: Key Points

…ne blistering disease characterized by autoantibodies against basement membrane zone proteins. Bullous pemphigoid generally presents in elderly patients as urticarial plaques and tense bullae, with eosinophilic spongiosis, edema, and subepidermal bli…

Therapeutic Strategies in Dermatology

Cicatricial Pemphigoid: Overview

…scarring, subepithelial bullous disorder that affects mucous membranes, including the conjunctivae. This disorder is thought to be mediated by autoantibodies directed at antigens in the epithelial basement membrane zone. The therapeutic strategy is…

A Clinical Atlas of 101 Common Skin Diseases

Bullous Pemphigoid and Herpes Gestationis

An inflammatory disease of older people; signs include widespread erythematous macules and patches, urticarial papules and plaques, and vesicles and bullae, the blisters often arising on urticarial plaques. Sometimes lesions are localized, e.g., to…

Therapeutic Strategies in Dermatology

Chronic Bullous Disease of Childhood: Overview

…e itching in association with linear deposition of IgA at the basement membrane zone. The clinical appearance resembles bullous pemphigoid. It often remits 2-3 years after onset and rarely lasts past age 10. Because this disorder affects children and…

Therapeutic Strategies in Dermatology

Bullous Pemphigoid: Clinical Case

…llow-up evaluation The biopsy demonstrates eosinophils at the basement membrane with epidermal spongiosis adjacent to a subepidermal blister filled with eosinophils; this is consistent with bullous pemphigoid The immunofluorescence studies show IgG a…

Histologic Diagnosis of Inflammatory Skin Diseases

Predominantly Basement Membrane Zone Fluorescence

…s diagnosed by direct immunofluorescence. Fluorescence at the basement membrane zone may be fine and discretely linear, thick and somewhat glassy linear, or granular. At times, the “boundaries” between these categories are blurred. For ex…

A Clinical Atlas of 101 Common Skin Diseases

Lupus Erythematosus

An inflammatory process that expresses itself in the skin in protean ways that are variations on a basic pathologic theme, and includes evanescent patches on the face (“butterfly blush”), scaly papules and plaques that resolve with atrop…

A Clinical Atlas of 101 Common Skin Diseases

Epidermolysis Bullosa

…but some of them not, that involve skin and sometimes mucous membranes, the blisters often developing after trauma and sometimes resulting in scarring and deformity. Longstanding atrophic scars are often the nidus for development of squamous-cell ca…

A Clinical Atlas of 101 Common Skin Diseases

Herpes Gestationis

An inflammatory disease of the second and third trimesters of pregnancy characterized by widespread urticarial papules and plaques accompanied by vesicles and bullae. Individual lesions are indistinguishable from those of bullous pemphigoid, clinica…

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