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Therapeutic Strategies in Dermatology

Cicatricial Pemphigoid: Overview

…scarring, subepithelial bullous disorder that affects mucous membranes, including the conjunctivae. This disorder is thought to be mediated by autoantibodies directed at antigens in the epithelial basement membrane zone. The therapeutic strategy is…

A Clinical Atlas of 101 Common Skin Diseases

Bullous Pemphigoid and Herpes Gestationis

An inflammatory disease of older people; signs include widespread erythematous macules and patches, urticarial papules and plaques, and vesicles and bullae, the blisters often arising on urticarial plaques. Sometimes lesions are localized, e.g., to…

Therapeutic Strategies in Dermatology

Chronic Bullous Disease of Childhood: Overview

…e itching in association with linear deposition of IgA at the basement membrane zone. The clinical appearance resembles bullous pemphigoid. It often remits 2-3 years after onset and rarely lasts past age 10. Because this disorder affects children and…

Therapeutic Strategies in Dermatology

Bullous Pemphigoid: Overview

…erly, in which circulating auto antibodies to epitopes in the basement membrane zone bind to this region and initiate a cascade of inflammatory events resulting in urticarial and bullous lesions. The therapeutic strategy is to reduce auto antibody pr…

Histologic Diagnosis of Inflammatory Skin Diseases

Predominantly Basement Membrane Zone Fluorescence

…s diagnosed by direct immunofluorescence. Fluorescence at the basement membrane zone may be fine and discretely linear, thick and somewhat glassy linear, or granular. At times, the “boundaries” between these categories are blurred. For ex…

A Clinical Atlas of 101 Common Skin Diseases

Epidermolysis Bullosa

…but some of them not, that involve skin and sometimes mucous membranes, the blisters often developing after trauma and sometimes resulting in scarring and deformity. Longstanding atrophic scars are often the nidus for development of squamous-cell ca…

A Clinical Atlas of 101 Common Skin Diseases

Herpes Gestationis

An inflammatory disease of the second and third trimesters of pregnancy characterized by widespread urticarial papules and plaques accompanied by vesicles and bullae. Individual lesions are indistinguishable from those of bullous pemphigoid, clinica…

A Clinical Atlas of 101 Common Skin Diseases

Lupus Erythematosus

An inflammatory process that expresses itself in the skin in protean ways that are variations on a basic pathologic theme, and includes evanescent patches on the face (“butterfly blush”), scaly papules and plaques that resolve with atrop…

A Clinical Atlas of 101 Common Skin Diseases

Dermatomyositis

An inflammatory disease of children and adults that tends to involve skin and skeletal muscle mostly, the findings in the skin being patches with the color of heliotrope, especially in the periocular region. The disease manifests itself as poikilode…

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