A Clinical Atlas of 101 Common Skin Diseases

Porphyria Cutanea Tarda

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A disease manifested chiefly in the skin by vesicles and bullae that appear on sites of trauma, especially the face and dorsa of the hands, often in conjunction with macular hyperpigmentation and hypertrichosis of a face and sclerodermoid changes on a chest.

A Clinical Atlas of 101 Common Skin Diseases

Porphyria Cutanea Tarda

A disease manifested chiefly in the skin by vesicles and bullae that appear on sites of trauma, especially the face and dorsa of the hands, often in conjunction with macular hyperpigmentation and hypertrichosis of a face and sclerodermoid changes on…

Therapeutic Strategies in Dermatology

Porphyria Cutanea Tarda

A disease manifested chiefly in the skin by vesicles and bullae that appear on sites of trauma, especially the face and dorsa of the hands, often in conjunction with macular hyperpigmentation and hypertrichosis of a face and sclerodermoid changes on…

Therapeutic Strategies in Dermatology

Porphyria Cutanea Tarda: Overview

Overview Porphyria cutanea tarda (PCT) is the most common porphyria. It is inherited as an autosomal dominant disorder in 20% of cases and is acquired in association with other disorders in the remaining 80% of cases. PCT is related to a deficiency…

Therapeutic Strategies in Dermatology

Photosensitivity Dermatoses: Overview

…hotosensitivity for systemic lupus erythematosus and porphyria cutanea tarda, with an ANA, Ro, La, and urine porphyrins. Chronic actinic dermatitis may mimic the S√©zary syndrome variant of cutaneous T-cell lymphoma. A skin biopsy and examination of t…

Therapeutic Strategies in Dermatology

Epidermolysis Bullosa Acquisita: Overview

…bution that heals with atrophic scarring (similar to porphyria cutanea tarda). EBA may also present as an inflammatory bullous disorder clinically similar to bullous pemphigoid, cicatricial pemphigoid, localized scarring pemphigoid, or linear IgA dis…

Histologic Diagnosis of Inflammatory Skin Diseases

Porphyria cutanea tarda

…of an infiltrate of inflammatory cells is a clue to porphyria cutanea tarda. “Caterpillar bodies” in the viable epidermis are suggestive strongly of porphyria cutanea tarda, but are not diagnostic of it unequivocally. Laboratory confirm…

A Clinical Atlas of 101 Common Skin Diseases

Sclerodermas

A generic term for at least two different inflammatory diseases that have in common hardening of the skin by virtue of thickening of bundles of collagen in the dermis and subcutis. One of those diseases manifests itself as localized or widespread pa…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…11.15.1B: Dermal papillae on volar skin preserved = Porphyria cutanea tarda ¬†Although venules and capillaries in the upper part of the dermis of porphyria cutanea tarda usually are rimmed by homogeneous eosinophilic material, that is not the case al…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Vesicular Dermatitis

…tterns of inflammatory diseases of the skin, namely, porphyria cutanea tarda for absence of inflammatory cells (Fig. 5.282 A&B), erythema multiforme for predominance of lymphocytes (Fig. 5.283 A&B), bullous pemphigoid (and its lookalike, herp…

Histologic Diagnosis of Inflammatory Skin Diseases

Predominantly Basement Membrane Zone Fluorescence

…small, superficial, dermal blood vessels, signifies porphyria cutanea tarda or pseudoporphyria (drug-induced or in patients with renal failure). Figure 8.5 Porphyria cutanea tarda (IgG). Thick “fuzzy” linear fluorescence at the baseme…