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Therapeutic Strategies in Dermatology

Herpes Zoster & Varicella: Key Points

Key Points Primary varicella infection (chickenpox) and herpes zoster are both caused by varicella zoster virus (VZV). Herpes zoster (shingles) represents activation of varicella zoster virus from cranial or dorsal root ganglion, thus affecting th…

Therapeutic Strategies in Dermatology

Urticaria: Initial Evaluation

Initial Evaluation Acute urticaria Migrating pruritic edematous papules and plaques of variable size, surrounded by erythema or an area of vasoconstriction (i.e., wheal). Can be intermittent, with the skin returning to normal appearance in less tha…

Therapeutic Strategies in Dermatology

Histiocytosis X/Langerhans Cell Histiocytoses: Overview

Overview Langerhans cell histiocytoses (Class I histiocytosis) are a group of disorders most common in childhood due to the accumulation or proliferation of a clonal population of cells bearing the phenotype of a Langerhans cell that has been arrest…

A Clinical Atlas of 101 Common Skin Diseases

Dermatitis Herpetiformis

An inflammatory process characterized by symmetrical distribution, especially on the skin of the scalp, overlying the scapulae and the sacrum, on the buttocks, and on the extensor surface of the extremities, of clusters of urticarial papules, papulo…

A Clinical Atlas of 101 Common Skin Diseases

Dermatofibrosarcoma Protuberans

A malignant nonepithelial neoplasm (a sarcoma) presumably of perineural fibrocytes that presents itself usually on the trunk, but sometimes elsewhere, such as the extremities, face, and scalp. A papule of it tends to become a plaque, a nodule, a tum…

A Clinical Atlas of 101 Common Skin Diseases

Dyshidrotic Dermatitis

A pruritic papular and vesicular inflammatory process of unknown cause that tends to affect the sides of fingers and toes, as well as palms and soles. The name “dyshidrotic” is misleading; the condition has no relation whatever to eccrin…

Therapeutic Strategies in Dermatology

Atopic Dermatitis: Key Points

Key Points Atopic dermatitis is an often chronic, intermittent disease. It is commonly found in association with allergic rhinitis, asthma, or other manifestations of atopy. There are two likely-related pathophysiologic mechanisms underlying the di…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Dermal Papilla?

…concluded that the established and conventional concept of the bulge as a single rounded protuberance at the side of an isthmus is not accurate and that this faulty perception has led to a conclusion incorrect about the role of the bulge in the activ…

Histologic Diagnosis of Inflammatory Skin Diseases

Suggested Readings

…l J Med 1999;341:491-497. Radonich M, Misciali C, Ackerman AB. Bulge-activation hypothesis. Part II. The bulge is not a bulge. Dermatopathol Pract Concept 1995;1(2):77-94. Stenn KS. Molecular insights into the hair follicle and its pathology: a revie…

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