Search Results for: bulge activation hypothesis

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Therapeutic Strategies in Dermatology

Urticaria: Initial Evaluation

…basophil or tissue mast cell degranulation triggered by IgE binding to antigens or through direct (non-IgE, non-immunologic) activation (by radiocontrast dye, NSAIDs, opiates, general anesthetics). This immune cell degranulation results in release…

Therapeutic Strategies in Dermatology

Histiocytosis X/Langerhans Cell Histiocytoses: Overview

…ation of a clonal population of cells bearing the phenotype of a Langerhans cell that has been arrested at an early stage of activation and is functionally deficient. This disorder is classified as single-system disease, multisystem disease, or…

Therapeutic Strategies in Dermatology

Sarcoidosis: Key Points

…disease is not uncommon and may be multifactorial. Patients with active sarcoidosis often have granuloma-mediated vitamin D activation and increased levels of 1,25 dihydroxy-vitamin D. They may develop hypercalcemia, and the presence of persistent…

Therapeutic Strategies in Dermatology

Granuloma Annulare: Key Points

…esized that blood vessel damage—potentially via immune complex deposition—may trigger a reactive inflammatory response; this hypothesis has been suggested for similar reactive granulomatous processes in the skin (such as palisaded neutrophilic and…

Therapeutic Strategies in Dermatology

Necrobiosis Lipoidica Diabeticorum: Key Points

…NL remains unclear. The observation of NL in the setting of diabetic patients with end-organ damage has lent credence to the hypothesis that NL represents a skin manifestation of tissue injury due to microvascular damage and potentially abnormal…

Therapeutic Strategies in Dermatology

Rosacea: Treatment

Subtypes of rosacea and their treatments Erythemato-telangiectatic (E-T) subtype Patients often complain of intolerance or sensitivity to topical products and cosmetics. This subtype is best treated with avoidance of flushing, photoprotection, and…

Therapeutic Strategies in Dermatology

Varicella & Herpes Zoster: Key Points

…yndrome marked by significant morbidity and mortality to both mother and child. Herpes Zoster Herpes zoster represents the reactivation of VZV from the cranial nerve or dorsal root ganglion with presentation of a painful vesicular rash in a…

Therapeutic Strategies in Dermatology

Atopic Dermatitis: Key Points

Key Points Atopic dermatitis is an often chronic, intermittent disease. It is commonly found in association with allergic rhinitis, asthma, or other manifestations of atopy. There are two likely-related pathophysiologic mechanisms underlying the…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Dermal Papilla?

…elevant to that phenomenon. Just as the original follicular germ in an embryo comes into being without the intercession of a bulge (bulges develop consequent to maturation of a follicular germ), so, too, it is in postnatal life—a germ that…

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