Search Results for: bulge activation hypothesis

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Therapeutic Strategies in Dermatology

Urticaria: Initial Evaluation

…basophil or tissue mast cell degranulation triggered by IgE binding to antigens or through direct (non-IgE, non-immunologic) activation (by radiocontrast dye, NSAIDs, opiates, general anesthetics). This immune cell degranulation results in release…

Therapeutic Strategies in Dermatology

Histiocytosis X/Langerhans Cell Histiocytoses: Overview

…ation of a clonal population of cells bearing the phenotype of a Langerhans cell that has been arrested at an early stage of activation and is functionally deficient. This disorder is classified as single-system disease, multisystem disease, or…

Therapeutic Strategies in Dermatology

Herpes Zoster & Varicella: Key Points

…yndrome marked by significant morbidity and mortality to both mother and child. Herpes zoster Herpes zoster represents the reactivation of VZV from the cranial or dorsal root ganglion with presentation of a painful vesicular rash in a dermatomal…

Therapeutic Strategies in Dermatology

Sarcoidosis: Key Points

…disease is not uncommon and may be multifactorial. Patients with active sarcoidosis often have granuloma-mediated vitamin D activation and increased levels of 1,25 dihydroxy-vitamin D. They may develop hypercalcemia, and the presence of persistent…

Therapeutic Strategies in Dermatology

Granuloma Annulare: Key Points

…esized that blood vessel damage—potentially via immune complex deposition—may trigger a reactive inflammatory response; this hypothesis has been suggested for similar reactive granulomatous processes in the skin (such as palisaded neutrophilic and…

A Clinical Atlas of 101 Common Skin Diseases

Dermatofibrosarcoma Protuberans

The term, dermatofibrosarcoma protuberans (DFSP), was coined by Hoffman in 1925 to signify a protuberant, often multinodular cutaneous tumor that showed progressive growth. Darier and Ferrand had described a case of the disease a year before, and…

Therapeutic Strategies in Dermatology

Rosacea: Treatment

Subtypes of rosacea and their treatments Erythemato-telangiectatic (E-T) subtype Patients often complain of intolerance or sensitivity to topical products and cosmetics. This subtype is best treated with avoidance of flushing, photoprotection, and…

A Clinical Atlas of 101 Common Skin Diseases

Dermatitis Herpetiformis

An inflammatory process characterized by symmetrical distribution, especially on the skin of the scalp, overlying the scapulae and the sacrum, on the buttocks, and on the extensor surface of the extremities, of clusters of urticarial papules,…

A Clinical Atlas of 101 Common Skin Diseases

Foreword

…rration, increased proliferation occurs, and nuclear atypia becomes marked. Other flawed concepts about melanoma include the hypothesis that melanoma is one disease (it is genetically diverse) and that the sun has little to do with its genesis (C to…

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