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A Clinical Atlas of 101 Common Skin Diseases

Lupus Erythematosus

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An inflammatory process that expresses itself in the skin in protean ways that are variations on a basic pathologic theme, and includes evanescent patches on the face (“butterfly blush”), scaly papules and plaques that resolve with atrophy and hyperpigmentation (classic discoid lupus erythematosus), arcuate, annular, and serpiginous lesions (subacute cutaneous lupus erythematosus), nonscaling plaques (tumid lupus erythematosus), subcutaneous nodules (lupus profundus), and blisters (bullous lupus erythematosus).

A Clinical Atlas of 101 Common Skin Diseases

Lupus Erythematosus

…at resolve with atrophy and hyperpigmentation (classic discoid lupus erythematosus), arcuate, annular, and serpiginous lesions (subacute cutaneous lupus erythematosus), nonscaling plaques (tumid lupus erythematosus), subcutaneous nodules (lupus profu…

Therapeutic Strategies in Dermatology

Lupus

…at resolve with atrophy and hyperpigmentation (classic discoid lupus erythematosus), arcuate, annular, and serpiginous lesions (subacute cutaneous lupus erythematosus), nonscaling plaques (tumid lupus erythematosus), subcutaneous nodules (lupus profu…

Therapeutic Strategies in Dermatology

Lupus: Key Points

…on with systemic symptoms. Non-specific skin signs of systemic lupus include chilblains (pernio), livedo reticularis, vasculitis, and other (non-oral) ulcerations. Cutaneous lupus erythematosus (CLE) may be divided into four subtypes: discoid lupus,…

Therapeutic Strategies in Dermatology

Pernio/Chilblains: Key Points

…symptoms may be an indication of a multisystem disease such as chilblain lupus erythematosus, a rare variant of systemic lupus Introduction Chilblains, also termed pernio, is a benign inflammatory condition of the distal skin which occurs in cold, d…

Therapeutic Strategies in Dermatology

Lupus: Treatment

…to the activity of cutaneous disease. Patients with cutaneous lupus lesions should undergo diagnostic evaluation for possible systemic lupus erythematosus. All patients with CLE should have laboratory parameters checked for the development of SLE at…

Therapeutic Strategies in Dermatology

Lupus: Clinical Cases

…rrent lesions on cheeks and scalp Negative workup for systemic lupus erythematosus (recent) Lesions are itchy, exacerbated by sun exposure No current treatment Initial evaluation Diagnosis: Discoid lupus (confirmed by biopsy) Desonide 0.05% ointmen…

Therapeutic Strategies in Dermatology

Pernio/Chilblains: Treatment

…lobulinemia or anti-phospholipid antibody syndrome. Pitfalls Chilblain lupus erythematosus may present with lesions identical to idiopathic chilblain (pernio). Patients with lesions that fail to resolve with warming or that persist for months, or p…

Therapeutic Strategies in Dermatology

Lupus: Initial Evaluation

Initial Evaluation Discoid lupus erythematosus Subacute lupus erythematosus Systemic lupus erythematosus Neonatal lupus erythematosus Lupus profundus Differential diagnosis Rosacea, face Ti…

Therapeutic Strategies in Dermatology

Lupus: References

…y of mycophenolate mofetil in antimalarial-resistant cutaneous lupus erythematosus, JAAD, Epub ahead of print. Kuhn A, Ruland V, Bonsmann G (2010) Cutaneous lupus erythematosus: Update of therapeutic options (part I and II), JAAD, Epub ahead of print…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Pernio, Perniosis, Lupus Pernio, Chilblain, and Chilblain Lupus?

…s, discoid LE resolved after 3–22 years (mean 13.3 years). The chilblain lesions have continued without resolution in all 11 patients.” Millard LG, Rowel NR. Chilblain lupus erythematosus (Hutchinson). Br J Dermatol 1978;98:497. “Severa…

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