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A Clinical Atlas of 101 Common Skin Diseases

Scars, Keloids, and Anetodermas

A type of fibrosing inflammation characterized clinically by lesions that at first are elevated and that do not extend beyond the exact site of injury and that in time tend to shrink, sometimes even becoming atrophic….

A Clinical Atlas of 101 Common Skin Diseases

Sclerodermas

A generic term for at least two different inflammatory diseases that have in common hardening of the skin by virtue of thickening of bundles of collagen in the dermis and subcutis. One of those diseases manifests itself as localized or widespread pa…

Histologic Diagnosis of Inflammatory Skin Diseases

Collagen

…re than 70% of the dry weight of the normal dermis consists of collagen (Fig. 1.79). The major collagens are Type I and Type III. Type I collagen has a molecular mass of about 290 KDa and accounts for approximately 80% of the total amount of collagen

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Fibrosing Dermatitis

…and electrodesiccation: calcification in a zone of degenerated collagen situated just below the epidermis. Calcification at the base of a zone of degenerated collagen is expected at times following injury by physical means, in this instance, curettag…

Histologic Diagnosis of Inflammatory Skin Diseases

Applicable Terms

…essing of a specimen. Figure 3.9 Cleft (suprabasal). COARSE COLLAGEN BUNDLES IN VERTICAL STREAKS: Collagen bundles thicker than normal for the papillary dermis and oriented parallel to one another and to elongated rete ridges (as well as to exagge…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…Nodular dermatitis, fibrohistiocytic + 10.20.13B: Keloidal collagen in haphazard array in conjunction with a markedly increased number of fibrocytes and histiocytes, some of them multinucleate = Dermatofibroma Keloidal collagen, when found in der…

Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

…Interstitially Scatter of eosinophils among bundles of collagen in the reticular dermis (and sometimes in septa of the subcutaneous fat). Click image to enlarge. + Neutrophils also scattered among collagen bundles in the reticular dermis = Ur…

Histologic Diagnosis of Inflammatory Skin Diseases

Errors and Reasons

…that condition presents itself in the skin clinically, loss of collagen also is contributory; “superficial atrophy” results largely from loss of collagen in dermal papillae, and “mid atrophy” (anetoderma) from loss of elastic…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…chemotactic to necrosis of histiocytes and to degeneration of collagen, or they could be residua of a small-vessel vasculitis that may have been responsible for a sequence of infarction, degeneration of collagen, and histiocytes aligned in a palisad…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Churg-Strauss Granuloma and Allergic Granulomatosis?

…tissue alteration in the vessel wall and in the extravascular collagen system. This tissue alteration, common to all cases here reported, comprised necrosis of eosinophilic exudate, severe “fibrinoid” collagen change, and granulomatous p…

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