Search Results for: collagen

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A Clinical Atlas of 101 Common Skin Diseases

Scars, Keloids, and Anetodermas

A type of fibrosing inflammation characterized clinically by lesions that at first are elevated and that do not extend beyond the exact site of injury and that in time tend to shrink, sometimes even becoming atrophic.

A Clinical Atlas of 101 Common Skin Diseases

Sclerodermas

…n hardening of the skin by virtue of thickening of bundles of collagen in the dermis and subcutis. One of those diseases manifests itself as localized or widespread patches and plaques (morphea) and by localized linear lesions (linear scleroderma), w…

Histologic Diagnosis of Inflammatory Skin Diseases

Collagen

…e than 70% of the dry weight of the normal dermis consists of collagen (Fig. 1.79). The major collagens are Type I and Type III. Type I collagen has a molecular mass of about 290 KDa and accounts for approximately 80% of the total amount of collagen

Histologic Diagnosis of Inflammatory Skin Diseases

Applicable Terms

…uperficial atrophy); when there is loss of elastic fibers and collagen in a rather discrete zone of reticular dermis, the skin pouches (mid-atrophy); when there is loss of adipocytes in the subcutaneous fat, a gully forms (deep atrophy). Clinically,…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…at the periphery of the lesion, namely, thickened bundles of collagen that seem to be enveloped by mesenchymal cells. In actuality, dermatofibroma is a granulomatous and fibrosing inflammatory disease, not a neoplastic or hyperplastic vascular one l…

Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

…te of inflammatory cells = Burn of any kind + Degeneration of collagen in a wedge shape = Infarction, e.g., in Degos” disease + Sparse superficial perivascular infiltrate of lymphocytes, vacuolar alteration, and a thinned epidermis sometimes =…

Histologic Diagnosis of Inflammatory Skin Diseases

Errors and Reasons

…c tissue in the reticular dermis especially, but also of some collagen, is responsible for anetoderma. Error: Apoptosis is not necrosis. Reason: In classic Virchowian pathology, necrosis is characterized cytopathologically by three signs, namely, pyk…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…tiocytes around loci of deposits of mucin and degeneration of collagen = Granuloma annulare This is a presentation stereotypical of granuloma annulare showing both the palisaded and interstitial patterns of granulomatous inflammation and lymphocytes…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Churg-Strauss Granuloma and Allergic Granulomatosis?

…tissue alteration in the vessel wall and in the extravascular collagen system. This tissue alteration, common to all cases here reported, comprised necrosis of eosinophilic exudate, severe “fibrinoid” collagen change, and granulomatous pr…

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