A Clinical Atlas of 101 Common Skin Diseases

Porokeratosis

A constellation of conditions that assumes various forms clinically but whose most dependable denominator in common (the exception being the punctate manifestation) is a keratotic ring around a central zone of atrophy, e.g., in a congenital expressi…

A Clinical Atlas of 101 Common Skin Diseases

Darier’s Disease

A genetically determined disorder in which numerous closely set keratotic papules are present on the skin, especially the trunk, in nail units, and on mucous membranes, particularly the palate, but also rarely in other parts of the gastrointestinal…

A Clinical Atlas of 101 Common Skin Diseases

Palmar and Plantar Keratoderma

A keratotic condition of the palms and soles, inherited usually, but sometimes acquired, in which involvement may be diffuse, circumscribed (including striate), or punctate….

Histologic Diagnosis of Inflammatory Skin Diseases

Images

….1A: Perivascular dermatitis, lymphocytic + 10.86.1B: Thin cornoid lamella = Porokeratosis, disseminated superficial actinic ┬áThe cornoid lamella on the left springs from an infundibulum. Cornoid lamellae also may emanate from eccrine ducts or su…

Histologic Diagnosis of Inflammatory Skin Diseases

Fox-Fordyce disease

…is of infundibular epidermis, including spongiotic vesiculate. Cornoid lamellation in infundibula sometimes Ballooning and vacuolar alteration, and individual dyskeratotic keratocytes in infundibula sometimes Lymphocytes in infundibular epidermis Foa…

Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

…d infiltrate of lymphocytes = Lichen planus-like keratosis + Cornoid lamellation = Porokeratosis, especially the disseminated superficial actinic type + Sclerosis in a band beneath the epidermis = Lichen sclerosus et atrophicus (superficial morph…

Histologic Diagnosis of Inflammatory Skin Diseases

Lichen planus

…findings histopathologic permit differentiation; for example, cornoid lamellation indicates disseminated superficial actinic porokeratosis, and hints of residual solar lentigo are indicative of lichen planus-like keratosis. A thickened basement memb…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Verruciform Xanthoma?

…epidermolytic hyperkeratosis, focal acantholytic dyskeratosis, cornoid lamellation, pale-cell acanthosis, and epithelial mucinosis and patterns that are wholly non-epithelial such as granular cellularity, flame figures, cholesterol clefts, Churg-Stra…

Histologic Diagnosis of Inflammatory Skin Diseases

Darier’s disease and simulators of it

…logous to that which occurs with epidermolytic hyperkeratosis, cornoid lamellation, pale-cell acanthosis, and epithelial mucinosis, distinctive patterns histopathologic of epithelium all. Papular acantholytic dermatosis of the genitocrural area is ch…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Sclerotic Fibroma?

…epidermolytic hyperkeratosis, focal acantholytic dyskeratosis, cornoid lamellation, pale-cell acanthosis, and epithelial mucinosis, and to patterns of non-epithelium like keloidal collagen. Each of those patterns are met with in a variety of circumst…