Search Results for: cyclosporine toxicity

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Therapeutic Strategies in Dermatology

Psoriasis: Principles of Psoriasis Management

…n tolerable doses of acitretin (10-25 mg daily), faster and more complete clearing, and lower cumulative doses of UV- light. Cyclosporine Cyclosporine (such as Neoral or Sandimmune) may be used to treat a variety of severe forms of psoriasis. The…

Therapeutic Strategies in Dermatology

Lichen Planus: Treatment

…Claravis, Sotret) 0.5-1 mg daily. Hydroxychloroquine 200 mg once to twice daily. This medication may have significant ocular toxicity and a baseline ophthalmologic exam should be performed prior to initiating the medication and every 3-6 months…

Therapeutic Strategies in Dermatology

Pyoderma Gangrenosum: Treatment

…g ulcers. Subsequent steps If the response to systemic steroids is inadequate and the process is extremely rapid, treat with cyclosporine A at an initial dose of 5-10 mg/kg/day (in addition to systemic steroids) with close monitoring for side…

Therapeutic Strategies in Dermatology

Sweet’s Syndrome (Acute Febrile Neutrophil Dermatosis): Treatment

…ry. In severe or refractory disease cyclosporine A, 5-10 mg/kg per day may induce a response. It may be necessary to utilize cyclosporine (in addition to systemic steroids) with close monitoring for side effects. Response should be dramatic and will…

Therapeutic Strategies in Dermatology

Hailey-Hailey Disease: Treatment

…times be useful in refractory disease, especially if generalized. Their use has largely been replaced by the use of BTX and cyclosporine. Pitfalls The use of prophylactic systemic antibiotics should be avoided if possible, to minimize the emergence…

Therapeutic Strategies in Dermatology

Private: Cutaneous Allergic (Leukocytoclastic) Vasculitis: Overview

…ent Steps Dapsone and colchicine may be combined for enhanced efficacy, sparing the use of immunosuppressives and minimizing toxicity from either medication (hemolysis and diarrhea, respectively). Hydroxychloroquine 250 mg twice daily, azathioprine…

Therapeutic Strategies in Dermatology

Superficial Fungal Infections: Therapy: Tinea capitis

…ed and not shared among family members. Pitfalls Griseofulvin, terbinafine, and ketoconazole can cause serious side effects, toxicity, and important drug interactions. All can rarely cause severe liver and hematologic toxicity, and pretreatment and…

Therapeutic Strategies in Dermatology

Pityriasis Rubra Pilaris: Overview

…t composed of vitamin A palmitate 9 million units in one pound of petrolatum may be applied twice daily. Watch for vitamin A toxicity. PRP is usually unresponsive or worsened by phototherapy, however, a few reports suggest improvement with PUVA…

Therapeutic Strategies in Dermatology

Photosensitivity Dermatoses: Overview

…be required. Therapeutic options include the following: Azathioprine 50–200 mg daily. Mycophenolate mofetil 1 g twice daily Cyclosporine A 3–5mg/kg/day. Thalidomide 100–200 mg daily. An appropriate pregnancy prevention program must be used for…

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