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Therapeutic Strategies in Dermatology

Psoriasis: Principles of Psoriasis Management

…e complete clearing, and lower cumulative doses of UV- light. Cyclosporine Cyclosporine (such as Neoral or Sandimmune) may be used to treat a variety of severe forms of psoriasis. The clinical response is often dramatic and may result in relatively…

Therapeutic Strategies in Dermatology

Lichen Planus: Treatment

Treatment Localized lichen planus Initial therapy First-line treatment: Superpotent topical steroid ointment or cream. Apply superpotent fluorinated topical steroid ointment or cream such as fluocinonide (such as Lidex), betamethasone (such as Dipro…

Therapeutic Strategies in Dermatology

Pityriasis Rubra Pilaris: Overview

…of petrolatum may be applied twice daily. Watch for vitamin A toxicity. PRP is usually unresponsive or worsened by phototherapy, however, a few reports suggest improvement with PUVA treatments. Likewise, cyclosporine may work on rare occasions, but…

Therapeutic Strategies in Dermatology

Dermatomyositis: Overview

Overview Patients with dermatomyositis (DM) often have multisystem involvement and therefore require a multidisciplinary approach. Consultation with a rheumatologist is strongly encouraged. A subset of patients will have only skin disease (amyopathi…

Therapeutic Strategies in Dermatology

Hailey-Hailey Disease: Overview

Overview Hailey-Hailey disease (HHD), also called benign familial pemphigus, is an autosomal-dominant disorder characterized by a defect in keratinocyte adhesion. HHD most frequently involves intertriginous areas, where exacerbations are triggered b…

Therapeutic Strategies in Dermatology

Sweet’s Syndrome (Acute Febrile Neutrophil Dermatosis): Treatment

…-sparing agents are necessary. In severe or refractory disease cyclosporine A, 5-10 mg/kg per day may induce a response. It may be necessary to utilize cyclosporine (in addition to systemic steroids) with close monitoring for side effects. Response s…

Therapeutic Strategies in Dermatology

Pyoderma Gangrenosum: Treatment

Treatment First-line therapy: The first-line therapy for pyoderma gangrenosum is comprised of two key elements: controlling inflammation and optimizing wound care. Inflammatory control may require systemic immunosuppression and/or the use of multip…

Therapeutic Strategies in Dermatology

Flushing: Key Points

…annel blockers, phosphodiesterase inhibitors, corticosteroids, cyclosporine, bromocriptine, IV contrast, vancomycin, chemotherapy agents, and classes of medications that result in serotonin toxicity (combination of monoamine oxidase inhibitor with se…

Therapeutic Strategies in Dermatology

Superficial Fungal Infections: Therapy: Tinea capitis

…terbinafine, and ketoconazole can cause serious side effects, toxicity, and important drug interactions. All can rarely cause severe liver and hematologic toxicity, and pretreatment and serial liver enzyme measurements and complete blood counts ever…

Therapeutic Strategies in Dermatology

Cutaneous Allergic (Leukocytoclastic) Vasculitis: Overview

Overview In approximately 50% of cases, cutaneous leukocytoclastic vasculitis (LCV) is caused by associated disease or underlying infection, or by a chemical or drug. The therapeutic strategy is to treat the underlying disorder. Recreational cocaine…

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