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Therapeutic Strategies in Dermatology

Psoriasis: Principles of Psoriasis Management

…alin Topical immunomodulators UVB PUVA Methotrexate Acitretin Cyclosporine Hydroxyurea Biologics Topical therapy Topical therapy alone offers excellent control for localized forms of psoriasis. Emollients. Liberal use of emollients to soften and…

Therapeutic Strategies in Dermatology

Hailey-Hailey Disease: Overview

…icosteroids (1 mg/kg/day prednisone) can lead to improvement. Cyclosporine A 5mg/kg/day is an alternative. These are not long-term management strategies, but they are useful to treat severe flares. Systemic retinoids, methotrexate, and dapsone, will…

Therapeutic Strategies in Dermatology

Lichen Planus: Treatment

…e to twice daily. This medication may have significant ocular toxicity and a baseline ophthalmologic exam should be performed prior to initiating the medication and every 3-6 months while on treatment. Oral lichen planus Most nonulcerative cases ar…

Therapeutic Strategies in Dermatology

Sweet’s Syndrome (Acute Febrile Neutrophil Dermatosis): Treatment

…sparing agents are necessary. In severe or refractory disease cyclosporine A, 5-10 mg/kg per day may induce a response. It may be necessary to utilize cyclosporine (in addition to systemic steroids) with close monitoring for side effects. Response sh…

Therapeutic Strategies in Dermatology

Pyoderma Gangrenosum: Treatment

…is inadequate and the process is extremely rapid, treat with cyclosporine A at an initial dose of 5-10 mg/kg/day (in addition to systemic steroids) with close monitoring for side effects. Response should be dramatic and will permit rapid reduction o…

Therapeutic Strategies in Dermatology

Superficial Fungal Infections: Therapy: Tinea capitis

…terbinafine, and ketoconazole can cause serious side effects, toxicity, and important drug interactions. All can rarely cause severe liver and hematologic toxicity, and pretreatment and serial liver enzyme measurements and complete blood counts every…

Therapeutic Strategies in Dermatology

Cutaneous Allergic (Leukocytoclastic) Vasculitis: Overview

…fficacy, sparing the use of immunosuppressives and minimizing toxicity from either medication (hemolysis and diarrhea, respectively). Hydroxychloroquine 250 mg twice daily, azathioprine 50-100 mg daily, or methotrexate 10-25 mg weekly may be used as…

Therapeutic Strategies in Dermatology

Pityriasis Rubra Pilaris: Overview

…of petrolatum may be applied twice daily. Watch for vitamin A toxicity. PRP is usually unresponsive or worsened by phototherapy, however, a few reports suggest improvement with PUVA treatments. Likewise, cyclosporine may work on rare occasions, but i…

Therapeutic Strategies in Dermatology

Dermatomyositis: Overview

…/day or methotrexate 10-50 mg once weekly have relatively low toxicity and good efficacy. Mycophenolate mofetil 0.5-1.5 mg twice daily may be used if the above agents are ineffective. 3. The dermatitis of DM is photosensitive. Maximum sun protection…

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