Search Results for: darier's sign

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A Clinical Atlas of 101 Common Skin Diseases

Darier’s Disease

A genetically determined disorder in which numerous closely set keratotic papules are present on the skin, especially the trunk, in nail units, and on mucous membranes, particularly the palate, but also rarely in other parts of the gastrointestinal…

Therapeutic Strategies in Dermatology

Darier’s Disease

A genetically determined disorder in which numerous closely set keratotic papules are present on the skin, especially the trunk, in nail units, and on mucous membranes, particularly the palate, but also rarely in other parts of the gastrointestinal…

Therapeutic Strategies in Dermatology

Darier’s Disease: Treatment

Treatment First-line therapy: The first-line therapy for Dariers disease is systemic retinoids. First steps The currently accepted primary treatment of moderate-to-severe Dariers disease is systemic retinoids. Isotretinoin and acitretin are equall…

Therapeutic Strategies in Dermatology

Darier’s Disease: Key Points

Key Points Dariers disease is a genodermatosis of autosomal dominant inheritance causing abnormalities of keratinization stemming from defects in calcium regulation in keratinocytes. The classic skin manifestation is an eruption of hyperkeratotic p…

Therapeutic Strategies in Dermatology

Darier’s Disease: References

References Abe M, Inoue C, Yokoyama Y, Ishikawa O. (2011). Successful treatment of Dariers disease with adapalene gel, Ped Derm, 28:197-198. Frezzini C, Cedro M, Leao JC, Porter S. (2006). Darier disease affecting the gingival and oral mucosal surf…

Therapeutic Strategies in Dermatology

Darier’s Disease: Clinical Case

Clinical Case Case 1 32-year-old male Presents with worsening Dariers disease No significant past medical history except for known diagnosis of Dariers. The patient was intermittently on oral isotretinoin, which controlled his disease during times

Therapeutic Strategies in Dermatology

Urticaria Pigmentosa / Mastocytosis: Key Points

…often contain granules of histamine. Stroking or rubbing a lesion of cutaneous mastocytosis can elaborate these signaling molecules, and often results in a localized wheal response, where the lesion while form a hive; this is called “Dariers sign.”…

A Clinical Atlas of 101 Common Skin Diseases

Epidermal Nevi

Epidermal nevi are hamartomas in which the epidermis is abnormal, being hyperkeratotic, and in which lesions are aligned along Blaschko’s lines….

Therapeutic Strategies in Dermatology

Hailey-Hailey Disease: Overview

…t microflora also can develop resistance to topical antibiotics. Hence, if long-term topical antibiotics are employed, clindamycin resistance may occur. Although HHD is classified with the disorders of cornification, such as Dariers disease an…

Therapeutic Strategies in Dermatology

Candidiasis: Key Points

…includes important considerations such as seborrheic dermatitis, tinea (superficial dermatophyte infection), inverse psoriasis, inverse pityriasis rosea, allergic or irritant contact dermatitis, deficiency dermatitis, Hailey-Hailey or Dariers

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