Search Results for: dermal dendritic cells

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A Clinical Atlas of 101 Common Skin Diseases

Epidermal Nevi

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Epidermal nevi are hamartomas in which the epidermis is abnormal, being hyperkeratotic, and in which lesions are aligned along Blaschko’s lines.

A Clinical Atlas of 101 Common Skin Diseases

Lupus Erythematosus

Lupus erythematosus (LE) is a multisystem autoimmune connective tissue disease that can have protean effects on the skin. In some patients only the skin is involved, while in others, life-threatening internal complications can arise, ranging from…

A Clinical Atlas of 101 Common Skin Diseases

Dermatofibrosarcoma Protuberans

…may also occur in children or the elderly. Its histogenesis remains uncertain. Historically, there have been many postulated cells of origin. This poorly circumscribed tumor likely originates from a pluripotent dermal mesenchymal cell with…

Therapeutic Strategies in Dermatology

Bullous Pemphigoid: Key Points

…between the keratinocytes. The eosinophils may be found in the epidermis itself, between keratinocytes, or lining up at the dermal/epidermal junction. When there is a blister cavity it will be subepidermal, with basal keratinocytes lifted up, and…

Therapeutic Strategies in Dermatology

Lupus: Treatment

…available only in cosmetic departments of large department stores. Pitfalls Topical and intralesional steroids may cause epidermal or dermal atrophy and can themselves produce pigmentary abnormalities. Prolonged or excessive usage can worsen the…

Therapeutic Strategies in Dermatology

Lymphomatoid Papulosis: Overview

Overview Lymphomatoid papulosis (LyP) is an inflammatory disorder affecting primarily the upper dermal blood vessels. It is characterized by the presence of CD30-positive lymphocytes (sometimes large and atypical) in the dermal infiltrate….

Therapeutic Strategies in Dermatology

Pruritic Urticarial Papules and Plaques of Pregnancy: Initial Evaluation

…ence (DIF) should be obtained. DIF in PUPPP is typically negative but rarely can have granular C3, IgM or IgA at the dermoepidermal junction. In contrast, pemphigoid gestationis is characterized by linear C3 at the dermoepidermal junction. Routine…

Histologic Diagnosis of Inflammatory Skin Diseases

Cells That Mediate Inflammation (Inflammatory Cells)

…c for neutrophils, eosinophils, lymphocytes, plasma cells, and histiocytes; whether mast cells, basophils, Langerhans” cells, dermal dendrocytes, fibrocytes, and platelets should be considered inflammatory cells is a matter yet unresolved. We…

Epidermal multinucleated giant cells are not always a histopathologic clue to a herpes virus infection: multinucleated epithelial giant cells in the epidermis of lesional skin biopsies from patients with acantholytic dermatoses can histologically mimic a herpes virus infection

Epidermal multinucleated giant cells are not always a histopathologic clue to a herpes virus infection: multinucleated epithelial giant cells in the epidermis of lesional skin biopsies from patients with acantholytic dermatoses can histologically mimic a herpes virus infection

…owever, laboratory studies and repeat biopsies established the correct diagnosis of their acantholytic dermatosis. Hence, epidermal multinucleated giant cells are not always a histopathologic clue to a herpes virus infection. Indeed, epithelial…

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