Search Results for: dermoepithelial interface

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Therapeutic Strategies in Dermatology

Lupus: Key Points

…c lupus erythematosus. The diagnosis of cutaneous lupus may be confirmed by skin biopsy, which in general reveals a vacuolar interface dermatitis, often in association with a lymphocytic infiltrate with plasma cells, epidermal atrophy, and mucin….

Histologic Diagnosis of Inflammatory Skin Diseases

Dermoepithelial Interface

…ed microfibril associated with elastin, which is absent from the skin of patients with Marfan’s syndrome. Although the dermoepithelial interface is known now to be composed of many elements, few of which were recognized 27 years ago when the…

Therapeutic Strategies in Dermatology

Dermatomyositis: Key Points

…e diagnosis is in doubt, a skin biopsy may sometimes be helpful. Histopathologically, dermatomyositis is characterized by an interface dermatitis with lymphocytes tagging the basal keratinocytes at the dermal/epidermal junction, accompanied by…

Therapeutic Strategies in Dermatology

Melanoma: Key Points

…involves only epidermis (in situ) II Invasion of papillary dermis only without involvement of the papillary-reticular dermal interface III Invasion to the papillary dermis without extension into the reticular dermis IV Invasion into the reticular…

Therapeutic Strategies in Dermatology

Pernio/Chilblains: Key Points

…ation. While not required for the diagnosis, patients with idiopathic pernio may undergo skin biopsy, and should features of interface dermatitis and histologic findings suggestive of lupus be noted, those patients should undergo an evaluation for…

Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

…hema multiforme + Lymphocytes, eosinophils, and neutrophils in conjunction with vacuolar alteration along the dermoepidermal interface and around and between venules = Fixed drug eruption + Lymphocytes and vacuolar alteration along the…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…ate against a diagnosis of discoid lupus erythematosus. In fact, it is a common finding, as is the smudged appearance of the interface between dermis and epidermis. 10.63.2A: Perivascular dermatitis, interface, vacuolar + 10.63.2B: Lymphocytes…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…apillary dermis and epidermis, and a sparse infiltrate of lymphocytes, rather than a lichenoid one, along the dermoepidermal interface. 10.66.4A: Perivascular dermatitis, interface, vacuolar + 10.66.4B: Lymphocytes along the dermoepidermal junction,…

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