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Therapeutic Strategies in Dermatology

Lupus: Key Points

Key Points Lupus is a disease that presents across a broad spectrum of cutaneous and systemic manifestations. It may be cutaneous-only or systemic with cutaneous manifestations; some patients with systemic lupus do not have cutaneous involvement. D…

Histologic Diagnosis of Inflammatory Skin Diseases

Dermoepithelial Interface

…he skin of patients with Marfan’s syndrome. Although the dermoepithelial interface is known now to be composed of many elements, few of which were recognized 27 years ago when the first edition of this book was published, many more doubtless wi…

Therapeutic Strategies in Dermatology

Melanoma: Principles of Management of Melanoma

Principles of Management of Melanoma Prognosis is largely determined by histologic features of the primary melanoma (depth of invasion and/or the degree to which the tumor has invaded the skin, as well as ulceration and mitotic index). The major ind…

Therapeutic Strategies in Dermatology

Pernio/Chilblains: Key Points

Key Points Chilblains (pernio) is a benign condition that occurs in cold, damp environments and presents with symmetric, distal, transient red-to-purple lesions on the extremities. Treatment is centered on keeping the patient warm and avoiding expo…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Perivascular Dermatitis

…ular and interstitial, superficial and deep. Figure 5.18 A. Interface dermatitis, vacuolar, superficial. B. Interface dermatitis, vacuolar, superficial and deep. Figure 5.19 A. Interface dermatitis, lichenoid, superficial. B. Interface dermatit…

Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

…conjunction with vacuolar alteration along the dermoepidermal interface and around and between venules = Fixed drug eruption + Lymphocytes and vacuolar alteration along the dermoepidermal interface and wedge-shaped perivascular and interstitial in…

Histologic Diagnosis of Inflammatory Skin Diseases

Applicable Terms

…voted to “confusing terms” later in this chapter.) DERMOEPITHELIAL INTERFACE [Gk. dermis (skin) + epithelial (pertaining to an epithelium) + NE. interface (boundary between two things)]: The junction between dermis and epithelial structur…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…t, it is a common finding, as is the smudged appearance of the interface between dermis and epidermis. 10.63.2A: Perivascular dermatitis, interface, vacuolar + 10.63.2B: Lymphocytes around venules and along the dermoepidermal junction = Lup…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…hocytes, rather than a lichenoid one, along the dermoepidermal interface. 10.66.4A: Perivascular dermatitis, interface, vacuolar + 10.66.4B: Lymphocytes along the dermoepidermal junction, vacuolar alteration, necrotic keratocytes, spongiosi…

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