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Therapeutic Strategies in Dermatology

Lupus: Key Points

…ent, with the focus of inflammation in the subcutaneous fat. A direct immunofluorescence testing of the skin biopsy will reveal characteristic patterns, depending on the form of cutaneous lupus. The goal of treatment for cutaneous lupus is directed a…

Therapeutic Strategies in Dermatology

Pruritic Urticarial Papules and Plaques of Pregnancy: Overview

…itic urticarial papules and plaques of pregnancy. A biopsy for direct immunofluorescence may be indicated. Scabies and other insect bites are morphologically similar to the pruritic papular rashes of pregnancy. Look carefully for burrows and take a h…

Therapeutic Strategies in Dermatology

Epidermolysis Bullosa Acquisita: Overview

…esired Consequences The major pitfall is not recognizing EBA. Direct immunofluorescence is essential in the evaluation of most bullous eruptions. Cyclosporin A has many side effects, and its prescription should be restricted to physicians with exper…

Therapeutic Strategies in Dermatology

Herpes Simplex: Treatment

…CV, acyclovir; VCV valacyclovir Initial therapy Perform viral direct immunofluorescence assay (DFA) and culture to confirm diagnosis of HSV. Culture for coexistent bacterial superinfection (usually S. aureus) and treat appropriately. For eczema herp…

Therapeutic Strategies in Dermatology

Dermatitis Herpetiformis: Key Points

…atopic disease. A skin biopsy, especially when performed with direct immunofluorescence studies, can be diagnostic. Serologic testing for tissue and epidermal transglutaminase may also be diagnostic. ELISA testing for anti-TTG IgA has an estimated s…

Therapeutic Strategies in Dermatology

Dermatitis Herpetiformis: Clinical Case

…mata of scabetic disease Diagnosis: DH Skin biopsies (H&E, direct immunofluorescence) are performed to confirm the diagnosis Treatment options discussed; patient opts for treatment to limit progression of new lesions. Dapsone 25 mg is prescribed…

Therapeutic Strategies in Dermatology

Impetigo: Initial evaluation

Initial evaluation Impetigo contagiosum Bullous lesions of impetigo Differential diagnosis Herpes simplex: May result in painful or burning, crusted grouped vesicles near the mouth or nares, often recurrent in the…

Histologic Diagnosis of Inflammatory Skin Diseases

Patterns of Direct Immunofluorescence

In the assessment of findings in a section of tissue by direct immunofluorescence, the prime considerations are two, namely, where precisely the predominant fluorescence is situated and which exactly of the immunoglobulins (IgG, IgA, IgM) or complem…

Therapeutic Strategies in Dermatology

Leukocytoclastic Vasculitis: Treatment

…skin biopsy of lesions to confirm the diagnosis. A biopsy for direct immunofluorescence (which reveals deposition at cutaneous superficial dermal vessels), in addition to biopsies for hematoxylin and eosin staining, may be helpful. For management of…

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