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A Clinical Atlas of 101 Common Skin Diseases

Drug Eruptions

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An inflammatory process that results from the effects of a drug administered systemically, e.g., by ingestion, inhalation, injection, or application rectally, and manifested usually by lesions distributed widely and symmetrically.

A Clinical Atlas of 101 Common Skin Diseases

Fixed Drug Eruption

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Circular orange-red-blue macule(s) or patch(es) that often becomes a papule(s) or plaque(s) and vesiculates, healing with hyperpigmentation, and that occurs repeatedly at the very same cutaneous and/or mucous membrane site(s), especially the genitalia, perioral region, and hands, in response to systemic administration of a particular drug or chemical, chief among them barbiturates and sulfonamides.

A Clinical Atlas of 101 Common Skin Diseases

Drug Eruptions

An inflammatory process that results from the effects of a drug administered systemically, e.g., by ingestion, inhalation, injection, or application rectally, and manifested usually by lesions distributed widely and symmetrically. Any of the many ex…

Therapeutic Strategies in Dermatology

Drug Eruptions

An inflammatory process that results from the effects of a drug administered systemically, e.g., by ingestion, inhalation, injection, or application rectally, and manifested usually by lesions distributed widely and symmetrically. Any of the many ex…

A Clinical Atlas of 101 Common Skin Diseases

Fixed Drug Eruption

…mical, chief among them barbiturates and sulfonamides. It is the only type of drug eruption that can be diagnosed with surety histopathologically, the findings in it being entirely specific, unlike the situation in drug eruptions of all other kinds….

Therapeutic Strategies in Dermatology

Drug Eruptions: Key Points

…tions represent a benign side effect; however, in rare cases, drug eruptions may have associated systemic complications with significant morbidity and/or mortality. There are four key steps to the evaluation of a drug rash: Is it a drug eruption? Is…

Therapeutic Strategies in Dermatology

Drug Eruptions: Therapy

…ents require systemic corticosteroids for management of their drug reaction. Note that systemic steroids should be used judiciously, as corticosteroids have been associated with increased morbidity when used in some systemic drug eruptions such as TE…

Therapeutic Strategies in Dermatology

Photosensitivity Dermatoses: Overview

Photosensitive drug eruptions, polymorphous light eruption, chronic actinic dermatitis (CAD -includes the conditions previously called photosensitive eczema, actinic reticuloid and persistent light reaction). Photosensitivity dermatoses are caused e…

Therapeutic Strategies in Dermatology

Drug Eruptions: Initial Evaluation

Initial Evaluation Differential diagnosis Drug hypersensitivity, i.e., DRESS (drug reaction with eosinophilia and systemic symptoms): Marked facial edema in association with a morbilliform eruption is concerning for DRESS. Viral ex…

Therapeutic Strategies in Dermatology

Linear IgA Dermatosis: Overview

…d the absence of gluten-sensitive enteropathy. Many cases are drug-induced, and culprit drugs include vancomycin, lithium, amiodarone, carbamazepine, captopril, penicillin, PUVA, furosemide, oxpprozin, IL-2, interferon-gamma, phenytoin, diclofenac, s…

Therapeutic Strategies in Dermatology

Balanitis: Overview

…ws therapy in the office to ensure compliance. Take a careful drug history to rule out a fixed drug eruption. Consider the possibility of an allergic contact dermatitis (e.g., from condoms or vaginal hygiene spray). Biopsy patients not responding to…

Therapeutic Strategies in Dermatology

Erythema Multiforme: Treatment

…lvadene should be avoided if there is any concern for a sulfa drug related EM or SJS. For oral lesions, an antiseptic mouthwash or hydrogen peroxide 30%, diluted 1:10, should be used t.i.d. Pain-alleviating mouthwash containing viscous lidocaine, dip…

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