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Therapeutic Strategies in Dermatology

Grover’s Disease / Transient Acantholytic Dermatosis: Clinical Cases

Clinical Case Case 1 49-year-old Caucasian male No significant past medical history except for childhood eczema and allergic rhinitis Recently returned from a one-month hiking trip to Australia Presents for management of severe pruritic eruption…

Therapeutic Strategies in Dermatology

Grover’s Disease / Transient Acantholytic Dermatosis: References

References Gupta M, Huang V, Linette G, Cornelius L (2012) Unusual complication of vemurafenib treatment of metastatic melanoma: exacerbation of acantholytic dyskeratosis complicated by Kaposi varicelliform eruption, JAAD, 148:966-968. Norman R and…

A Clinical Atlas of 101 Common Skin Diseases

Porokeratosis

A constellation of conditions that assumes various forms clinically but whose most dependable denominator in common (the exception being the punctate manifestation) is a keratotic ring around a central zone of atrophy, e.g., in a congenital expressi…

A Clinical Atlas of 101 Common Skin Diseases

Darier’s Disease

A genetically determined disorder in which numerous closely set keratotic papules are present on the skin, especially the trunk, in nail units, and on mucous membranes, particularly the palate, but also rarely in other parts of the gastrointestinal…

A Clinical Atlas of 101 Common Skin Diseases

Palmar and Plantar Keratoderma

A keratotic condition of the palms and soles, inherited usually, but sometimes acquired, in which involvement may be diffuse, circumscribed (including striate), or punctate….

A Clinical Atlas of 101 Common Skin Diseases

Epidermal Nevi

Epidermal nevi are hamartomas in which the epidermis is abnormal, being hyperkeratotic, and in which lesions are aligned along Blaschko’s lines….

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…corneocytes in basket-weave pattern above foci of acantholytic dyskeratosis. A tad of parakeratosis is seen in the focus of acantholytic dyskeratosis shown at high magnification. 10.44.4A: Vesicular dermatitis, intraepidermal, acantholytic +…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Vesicular Dermatitis

…too, for acantholytic dyskeratotic acanthoma, but acantholytic dyskeratosis does occur in an inflammatory disease, namely, the “Darier manifestation” of Grover’s disease (Fig. 5.273 A&B). A focus of “acantholytic dyskerato…

Histologic Diagnosis of Inflammatory Skin Diseases

Grover’s disease

…atosis characterized histopathologically by focal acantholytic dyskeratosis, i.e., acantholytic dyskeratotic acanthoma, and from an incidental finding histopathologic of focal acantholytic dyskeratosis. Such a focus may be indistinguishable, too, fro…

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