Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Actinic Granuloma?

“Ring-shaped inflammatory lesions sometimes develop in the abnormal, ‘elastotic’ connective tissue of the skin damaged by the sun and heat …” “Microscopic sections show that there is an infiltrate composed mainly…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.15.1A: Nodular dermatitis, granulomatous + 10.15.1B: Histiocytes in a palisade in the upper part of the dermis in conjunction with a perivascular lymphoplasmacytic infiltrate = Crohn’s disease The palisaded granulomas in t…

Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

In this section, algorithms used to reach specific diagnosis are predicated on “nonspecific” findings recognized best at higher magnification. Other changes requisite for specific diagnoses, i.e., denominators that are essential, then ar…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.43.1A: Nodular dermatitis, granulomatous + 10.43.1B: Interstitial and palisaded array of histiocytes around loci of deposits of mucin and degeneration of collagen = Granuloma annulare This is a presentation stereotypical of gran…

Histologic Diagnosis of Inflammatory Skin Diseases

Errors and Reasons

Error: Abortive is an accurate modifier of particular pathologic processes, e.g., abortive dermatofibroma, abortive morphea, and abortive T-cell lymphoma. Reason: The idea itself is abortive! For example, what is called “abortive T-cell lympho…

Dermatology Practical & Conceptual

Actinic granuloma

Actinic granuloma is a rare, idiopathic disorder of middle-aged adults that always appears in sun-exposed skin [1,2]. It is a form of granulomatous dermatosis characterized by annular plaques with central atrophy and raised erythematous margins that…

Histologic Diagnosis of Inflammatory Skin Diseases

Kimura’s disease

Kimura’s disease Synonyms Eosinophilic lymphofolliculitis Presentation stereotypical Age and sex Young men, especially Asians Distribution of lesions Head, neck, and trunk Individual lesions Firm nodules and tumors, some gigantic, above which…

Differential Diagnosis in Dermatopathology

Discussions

The interstitial type of granuloma annulare and the interstitial type of mycosis fungoides have several findings histopathologic in common as follows: Perivascular infiltrates of lymphocytes may involve both superficial and deep plexuses; mononuclea…