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Therapeutic Strategies in Dermatology

Melanoma: Treatment

…lus physical examination (especially noting any enlarged lymph nodes). Depending on the histology, blood test (CBC, LDH, ALT), ultrasonography of the regional lymph node, abdominal ultrasound, and a chest x-ray might be recommended. Additional imagin…

Therapeutic Strategies in Dermatology

Melanoma: Key Points

…of resection of the primary tumor? Which patients should have elective regional lymph node dissection? Is there an efficient adjuvant treatment to prevent relapses, which patients will benefit from it? Referral to regional centers or consultation…

Therapeutic Strategies in Dermatology

Melanoma: Clinical Cases

…l excision with 2 cm margins and elects to have sentinel lymph node mapping and dissection, which reveals no affected lymph nodes Brain, chest, abdominal, and pelvic CT scans do not reveal evidence of metastatic disease Subsequent follow-up Follow-…

Therapeutic Strategies in Dermatology

Cutaneous T-Cell Lymphoma/ Mycosis Fungoides: Overview

…plaques < o r> 10% body surface area with palpable lymph nodes without pathologic involvement Stage IIB-tumors with or without palpable lymph nodes in the absence of pathologic involvement Stage III-erythroderma with or without palpable lymph n…

Therapeutic Strategies in Dermatology

Keloids and Hypertrophic Scars: Treatment

Treatment First-line therapy: Intralesional corticosteroids remain the first-line therapy for keloids and hypertrophic scars. They may be effective in 50-100% of cases but may be associated with recurrence in up to half of cases. Treatment of keloid…

Therapeutic Strategies in Dermatology

Melanoma: References

References National Cancer Institute: http://www.cancer.gov (2009) Melanoma Treatment (PDQ). Dummer R et al (2008) Cutaneous malignant melanoma: ESMO clinical recommendations for diagnosis, treatment and follow-up, Ann Oncol, 19:ii86-88. Garbe C et…

Therapeutic Strategies in Dermatology

Extramammary Paget’s/Paget’s Disease: Overview

Overview The diagnosis of Paget’s disease or extramammary Paget’s is made when Paget cells are identified in histopathologic specimens from involved skin. The term Paget’s disease is used when the cutaneous lesion is identified inv…

Therapeutic Strategies in Dermatology

Kaposi’s Sarcoma: Overview

Overview Kaposi’s sarcoma (KS) results from endothelial cell proliferation caused by infection with human herpesvirus 8 and occurs in four settings: classic KS, African (endemic) KS, immunosuppressive-associated KS, and AIDS-associated KS. The…

Therapeutic Strategies in Dermatology

Urticaria Pigmentosa / Mastocytosis: Key Points

Key Points Mastocytosis can occur at any age, and may involve the skin, or affect internal organs including the bone marrow and liver/spleen/lymphatic tissues Urticaria pigmentosa is a form of cutaneous mastocytosis most common in childhood, char…

Therapeutic Strategies in Dermatology

Melanoma: Principles of Management of Melanoma

…olecular features, anatomic location, spread to regional lymph nodes, and clinical features may also influence clinical outcome. Clinical staging is predicated on whether the tumor has spread to regional lymph nodes or distant sites; the American Joi…

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