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Therapeutic Strategies in Dermatology

Melanoma: Key Points

…and mortality. Evidence clarifying which patients should have elective regional lymph node dissection remains somewhat controversial. In questionable cases, referral to regional centers or consultation with regional experts is recommended. New thera…

Therapeutic Strategies in Dermatology

Melanoma: Treatment

…for more extensive baseline evaluation┬ásuch as sentinel lymph node biopsy and/or searching for metastases (CT or MRI of the brain, chest, abdomen or pelvis, or PET CT). Ancillary therapy The decision to pursue regional sentinel lymph node dissectio…

Therapeutic Strategies in Dermatology

Melanoma: Clinical Cases

…l excision with 2 cm margins and elects to have sentinel lymph node mapping and dissection, which reveals 2 of 8 lymph nodes affected Brain, chest, abdominal, and pelvic CT scans reveal evidence of metastatic disease in the lung and liver. Blood work…

Therapeutic Strategies in Dermatology

Cutaneous T-Cell Lymphoma/ Mycosis Fungoides: Overview

…plaques < o r> 10% body surface area with palpable lymph nodes without pathologic involvement Stage IIB-tumors with or without palpable lymph nodes in the absence of pathologic involvement Stage III-erythroderma with or without palpable lymph n…

Therapeutic Strategies in Dermatology

Melanoma: References

References Balch CM et al (2009) Final version of the 2009 AJCC Melanoma staging and classification, JCO, 27: 6199-6206. Chapman PB, Hauschild A, Robert C, et al (2011) Improved survival with vemurafenib in melanoma with BRAF V600E mutation, N Engl…

Therapeutic Strategies in Dermatology

Keloids and Hypertrophic Scars: Treatment

Treatment First-line therapy: Intralesional corticosteroids remain the first-line therapy for keloids and hypertrophic scars. They may be effective in 50-100% of cases but may be associated with recurrence in up to half of cases. Treatment of keloid…

Therapeutic Strategies in Dermatology

Kaposi’s Sarcoma: Overview

Overview Kaposi’s sarcoma (KS) results from endothelial cell proliferation caused by infection with human herpesvirus 8 and occurs in four settings: classic KS, African (endemic) KS, immunosuppressive-associated KS, and AIDS-associated KS. The…

Therapeutic Strategies in Dermatology

Extramammary Paget’s/Paget’s Disease: Overview

Overview The diagnosis of Paget’s disease or extramammary Paget’s is made when Paget cells are identified in histopathologic specimens from involved skin. The term Paget’s disease is used when the cutaneous lesion is identified inv…

Therapeutic Strategies in Dermatology

Urticaria Pigmentosa / Mastocytosis: Key Points

Key Points Mastocytosis can occur at any age, and may involve the skin, or affect internal organs including the bone marrow and liver/spleen/lymphatic tissues Urticaria pigmentosa is a form of cutaneous mastocytosis most common in childhood, char…

A Clinical Atlas of 101 Common Skin Diseases

Melanoma

A malignant neoplasm of melanocytes that, in the skin, begins as a macule and may become a patch or a papule. A flat lesion of melanoma tends to be asymmetrical, poorly circumscribed with a scalloped, jagged, or notched border, and variegate, mostly…

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