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Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

…0;Eosinophilic Abscesses” Discrete collections of eosinophils in an epidermis, a misnomer because the “abscesses” are neither eosinophilic nor composed of neutrophils and, therefore, are best referred to as collections of eos…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…but also in a variety of other inflammatory diseases in which eosinophils are numerous. 10.5.2A: Vesicular dermatitis, intraepidermal, spongiotic and ballooned + 10.5.2B: Perivascular and interstitial infiltrate replete with eosinophils =…

Histologic Diagnosis of Inflammatory Skin Diseases

Cells That Mediate Inflammation (Inflammatory Cells)

…x consists predominantly of eosinophil peroxidase, even though eosinophils appear to have much less bactericidal activity than neutrophils. Phagocytosis by eosinophils is restricted mainly to granules of mast cells and to complexes of antigen and ant…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Perivascular Dermatitis

…lar and interstitial infiltrate in which lymphocytes and a few eosinophils are present around venules and eosinophils are scattered in the interstitium should call to mind pruritic urticarial papules and plaques of pregnancy (PUPPP) (Fig. 5.27 A&…

Histologic Diagnosis of Inflammatory Skin Diseases

Arthropod assaults

…response to a “bite” of an insect Lymphocytes and eosinophils around venules, and eosinophils scattered in the interstitium of the reticular dermis; a few neutrophils may be discernible Slight edema of the papillary dermis A discrete foc…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Eosinophilic Cellulitis (Wells’ Syndrome)?

…b. Histologically there is oedema and dermal infiltration with eosinophils. The resolving stage of granulomatous dermatitis lasts about six weeks with brawny, slate coloured oedema. Histologically the dermis is infiltrated with eosinophils and histio…

Histologic Diagnosis of Inflammatory Skin Diseases

Herpes gestationis

…) Perivascular and interstitial infiltrate of lymphocytes and eosinophils Eosinophils scattered throughout the upper part of the reticular dermis, in the edematous papillary dermis, and along the dermoepidermal junction Eosinophils often in the epid…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Vesicular Dermatitis

…inflammatory cells (in this instance mixed, of lymphocytes and eosinophils) is irrelevant to coming to that diagnosis with specificity. As a rule, however, eosinophils complement lymphocytes. In most instances, the place where a blister resides withi…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…nterface, vacuolar, and spongiotic + 10.10.1B: Innumerable eosinophils in the edematous papillary dermis and in the acanthotic epidermis = Bullous pemphigoid, urticarial Eosinophils in the epidermis induce spongiosis that, at times, leads to form…

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