Search Results for: eosinophils

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Therapeutic Strategies in Dermatology

Bullous Pemphigoid: Key Points

…target antigens (BP180 and BP230) are components of the hemidesmosome which binds the basement keratinocytes to the dermis. Eosinophils are typically present in the affected skin and at the bullae (and urticarial plaques) in patients with BP….

Therapeutic Strategies in Dermatology

Bullous Pemphigoid: Clinical Case

…ile waiting the biopsy results, start with high potency topical corticosteroids Follow-up evaluation The biopsy demonstrates eosinophils at the basement membrane with epidermal spongiosis adjacent to a subepidermal blister filled with eosinophils;…

Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

…scular and interstitial infiltrate of lymphocytes and eosinophils = Incontinentia pigmenti, vesicular stage + Collections of eosinophils in the epidermis and numerous eosinophils in the upper part of the dermis = Toxic erythema of the newborn  …

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…e characteristic of a reaction to the bite of a spider. 22A: Perivascular and interstitial dermatitis + 22B: Lymphocytes and eosinophils around blood vessels, and eosinophils, many of them degranulated and contiguous with bundles of degenerated…

Histologic Diagnosis of Inflammatory Skin Diseases

Cells That Mediate Inflammation (Inflammatory Cells)

…ential to understanding various inflammatory diseases of the skin as they are scrutinized through a conventional microscope. Eosinophils Eosinophils, like other granulocytes, originate in the bone marrow and develop from myeloid stem cells. From…

Histologic Diagnosis of Inflammatory Skin Diseases

Arthropod assaults

…tions often are termed, incorrectly, “eosinophilic abscesses”; an abscess is a collection of neutrophils, not of eosinophils. Collections of eosinophils in the reticular dermis may assume the appearance of what some authors imagine to…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Eosinophilic Cellulitis (Wells’ Syndrome)?

…skin (and subcutaneous fat). The pattern sometimes is joined by histiocytes arrayed in a palisade around granular debris of eosinophils (foreign-body granulomatous response to clusters of granules of eosinophils, which are an expected happening in…

Histologic Diagnosis of Inflammatory Skin Diseases

Herpes gestationis

…in conjunction with spongiosis Fully developed (vesicular) Perivascular and interstitial infiltrate of lymphocytes and many eosinophils Numerous eosinophils throughout the edematous upper part of the dermis Subepidermal blister within which…

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