Search Results for: familial melanopathy with gigantic melanocytes

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Therapeutic Strategies in Dermatology

Pernio/Chilblains: Key Points

Key Points Chilblains (pernio) is a benign condition that occurs in cold, damp environments and presents with symmetric, distal, transient red-to-purple lesions on the extremities. Treatment is centered on keeping the patient warm and avoiding…

Therapeutic Strategies in Dermatology

Porokeratosis: Overview

…s must be biopsied. Porokeratosis is an autosomally dominantly inherited genetic trait. Genetic counseling is appropriate in familial cases. Topical 5-FU therapy can cause severe skin inflammation. Patients must be counseled carefully and followed…

Therapeutic Strategies in Dermatology

Facial Melanosis, Melasma: Key Points

…er cutaneous lip. It results from increased epidermal melanin pigment in the epidermis, dermis, or both; increased number of melanocytes or dermal melanophages in the dermis may also result in melasma. It usually appears in association with estrogen…

Therapeutic Strategies in Dermatology

Melanoma: Key Points

…e management of metastatic melanoma and extend survival for affected patients. Introduction Melanoma is a malignant tumor of melanocytes residing in skin, mucosal sites, eye, and meninges. In the United States, the incidence is 10-25 per 100,000…

Therapeutic Strategies in Dermatology

Hailey-Hailey Disease: Key Points

…ic antibiotics as well as systemic immunomodulators may be employed. Introduction Hailey-Hailey disease (HHD), also known as familial benign chronic pemphigus, is a rare autosomal dominantly inherited genodermatosis with complete penetrance in…

Therapeutic Strategies in Dermatology

Hailey-Hailey Disease: References

…e is caused by mutations in ATP2C1 encoding a novel Ca(2+) pump. Hum Mol Genet. 2000;9(7):1131-1140. Tchernev G, Cardoso JC. Familial benign chronic pemphigus (Hailey-Hailey Disease): use of topical immunomodulators as a modern treatment option. Rev…

Therapeutic Strategies in Dermatology

Urticaria Pigmentosa / Mastocytosis: References

…sis and treatment of cutaneous mastocytosis in children. Am J Clin Dermatol 12, 259-270. Fett NM, Teng J, Longley BJ (2013). Familial urticarial pigmentosa: report of a family and review of the role of KIT mutations. Am J Dermatopathol, 35, 113-116…

Therapeutic Strategies in Dermatology

Urticaria Pigmentosa / Mastocytosis: Key Points

…curs in patients of all ethnic backgrounds and in both men and women. Most cases are sporadic, but there are rare cohorts of familial cases, including disease reported in monozygotic twins. Cases of adult mastocytosis have been identified with…

Histologic Diagnosis of Inflammatory Skin Diseases

Melanocytes

…on of the body, being more numerous in the skin of the face (up to 2,900 melanocytes per mm2) than on the trunk (up to 1,250 melanocytes per mm2). Figure 1.62 Epidermal melanocytes, when viewed through a conventional microscope, appear as…

Multiple familial trichoepithelioma: confirmation via dermoscopy

Multiple familial trichoepithelioma: confirmation via dermoscopy

…cated in the chromosome 16q12-q13 in roughly 40% of cases [5]. This gene is a tumor suppressor gene altered in both multiple familial trichoepithelioma, familial cylindromatosis and in the Brooke-Spiegler syndrome [5]. In fact, those three…

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