Search Results for: fibrin

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A Clinical Atlas of 101 Common Skin Diseases

Allergic (Leukocytoclastic) Vasculitis

…ystemic inflammatory process involving venules by deposits of fibrin within their wall in conjunction with neutrophils and nuclear “dust” of neutrophils in the dermis and, at times, the subcutaneous fat. The clinical manifestations are ur…

A Clinical Atlas of 101 Common Skin Diseases

Livedo Vasculitis and Livedo Reticularis

A type of small-vessel vasculitis (venulitis) of the skin, occurring especially in the vicinity of the ankle, characterized at first by purpuric macules and patches that, in time, may become hemorrhagic blisters that ulcerate and heal with white, st…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…d erythrocytes = Leukocytoclastic vasculitis, early Even when fibrin is not present in the wall of venules, as here, findings such as those pictured suffice for diagnosis of leukocytoclastic vasculitis. In short, the changes shown are specific for th…

Histologic Diagnosis of Inflammatory Skin Diseases

Livedo vasculitis

…ate of lymphocytes and interstitial infiltrate of neutrophils Fibrin in the wall and fibrin thrombi in the lumen of venules in the upper part of the dermis mostly; sometimes, the lower half of the dermis is affected and, episodically, the subcutaneou…

Histologic Diagnosis of Inflammatory Skin Diseases

Rheumatoid nodule

…developed Perivascular infiltrates of lymphocytes Deposits of fibrin of various sizes in the deep reticular dermis and/or the subcutaneous fat Neutrophils and nuclear “dust” of neutrophils scattered in the mass of fibrin Fibrin surrounded…

Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

…21; of neutrophils in dermal papillae and in conjunction with fibrin in subepidermal spaces; no increase in dermal mucin = Dermatitis herpetiformis/linear IgA dermatosis + Neutrophils and nuclear “dust” of neutrophils in perivascular and…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Lymphocytic Vasculitis?

…lymphocytes in and around the walls of venules accompanied by fibrin deposition in their walls or lumens, or both.” Carlson JA, Mihm MC, Leboit PE. Cutaneous lymphocytic vasculitis: a definition, a review, and a proposed classification. Semin D…

Histologic Diagnosis of Inflammatory Skin Diseases

Behçet’s Disease

…d interstitial location, as well as in infundibular epidermis Fibrin in the wall of venules and/or thrombi in the lumen of venules in some lesions Intraepidermal vesicles sometimes, secondary to ballooning Ulceration episodic secondary to vasculitis…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…olonged rubbing. 10.23.16A: Fibrosing dermatitis + 10.23.16B: Fibrin, an ulcer, and epidermal hyperkeratosis, hypergranulosis, and acanthosis = Chondrodermatitis nodularis helicis The ulcer, fibrin, and fibrosing granulation tissue are signs of susta…

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