Histologic Diagnosis of Inflammatory Skin Diseases

Gas gangrene

Gas gangrene Synonyms Clostridial myonecrosis Presentation stereotypical Age and sex Usually adults of both sexes Distribution of lesions Localized to sites of deep wounds Individual lesions Dusky erythematous plaques and hemorrhagic bullae through…

Histologic Diagnosis of Inflammatory Skin Diseases

Gas gangrene

Therapeutic Strategies in Dermatology

Spider Bites: Key Points

Key Points Spiders are 8-legged (arthropod) members of the order Araneae. Spider bites result from a self-defense reaction when a spider feels threatened and typically arise due to inadvertent meeting with a spider (i.e., accidental). There are sev…

A Clinical Atlas of 101 Common Skin Diseases

Lupus Erythematosus

An inflammatory process that expresses itself in the skin in protean ways that are variations on a basic pathologic theme, and includes evanescent patches on the face (“butterfly blush”), scaly papules and plaques that resolve with atrop…

Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

…s, and many Gram-positive bacilli in the subcutis especially = Gas gangrene + Rim of homogenous eosinophilic material around small vessels in the upper part of the dermis and abundant solar elastosis = Porphyria cutanea tarda + Rim of homogenous…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…10.40.1C + 10.40.1D + 10.40.1E + 10.40.1F = Gas gangrene   Clostridium perfringens, the causative organism of this process, sometimes creates serum-filled spaces that house innumerable erythrocytes. When bacilli in those erythrocyt…

Histologic Diagnosis of Inflammatory Skin Diseases

Lupus erythematosus

…of a macule of guttate psoriasis. Degos’ disease, acral gangrene, i.e., of fingers and toes, and deep ulcers near internal malleoli are associated with thrombi in vessels situated in the deep reticular dermis and, in the case of gangrene of ac…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Follicular Degeneration Syndrome?

“An irreversible alopecia of the scalp occurs in negro women who straighten their hair with hot combs. The disease is common and distinctive, clinically and histopathologically. . . . Hot petrolatum used with the comb causes a chronic inflamm…

Histologic Diagnosis of Inflammatory Skin Diseases

Drug eruptions

Drug eruptions Synonyms Dermatitis medicamentosa Presentation stereotypical Age and sex Any age or either sex, but most common in older persons who take many medications. Immunosuppressed patients, among them those infected with the human immunodefi…

Histologic Diagnosis of Inflammatory Skin Diseases

Disseminated intravascular coagulopathy

Disseminated intravascular coagulopathy Synonyms Disseminated intravascular coagulation Presentation stereotypical Age and sex Usually adults of both sexes, but sometimes children Distribution of lesions Extremities especially Individual lesions Hem…