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Therapeutic Strategies in Dermatology

Melanoma: Key Points

…ulceration, regression, mitotic index), by the location of the tumor, by the presence of regional or distant metastases, and by the patient characteristics (age, medical co-morbidities). Increased tumor thickness is associated with significant morbid…

Therapeutic Strategies in Dermatology

Vascular Birthmarks: Key Points

Key Points Vascular birthmarks are cutaneous vascular lesions present at, or shortly after, birth. They may be categorized as vascular tumors or vascular malformations. The term hemangioma has previously been used to describe many common, typicall…

Therapeutic Strategies in Dermatology

Psoriasis: Principles of Psoriasis Management

Principles of Psoriasis Management Topical therapy is usually appropriate for treatment of patients with less than 10% body surface area (see table below). Systemic therapies (see table below) are indicated when one or more of the following are pre…

Therapeutic Strategies in Dermatology

Flushing: Clinical Case

…but urinary 5-HIAA is very elevated, suggestive of a carcinoid tumor. Follow-up imaging with abdominal CT scan and radiolabeled octreotide scan reveal a jejunoileal tumor highly suspicious for a midgut carcinoid tumor. There are no metastatic lesions…

Therapeutic Strategies in Dermatology

Melanoma: Principles of Management of Melanoma

…ary melanoma (depth of invasion and/or the degree to which the tumor has invaded the skin, as well as ulceration and mitotic index). The major independent risk factor is tumor thickness measured in millimeters (Breslow depth). Depth of invasion is al…

Therapeutic Strategies in Dermatology

Melanoma: Treatment

Treatment Initial therapy First-line: Surgical excision For diagnosis, complete excisional biopsy with minimal margins, pathologically evaluated at multiple levels to determine the tumor thickness, ulceration, mitotic index, evidence of regression,…

A Clinical Atlas of 101 Common Skin Diseases

Melanoma

…ay become a plaque or upon it may develop a papule, nodule, or tumor. A papule may develop into a nodule or tumor. The surface of an elevated lesion of melanoma tends to be uneven. When a melanoma is no longer flat, it has capability to metastasize a…

Differential Diagnosis in Dermatopathology

Apocrine mixed tumor vs. Eccrine mixed tumor

…ay become a plaque or upon it may develop a papule, nodule, or tumor. A papule may develop into a nodule or tumor. The surface of an elevated lesion of melanoma tends to be uneven. When a melanoma is no longer flat, it has capability to metastasize a…

Therapeutic Strategies in Dermatology

Kaposi’s Sarcoma: Overview

Overview Kaposi’s sarcoma (KS) results from endothelial cell proliferation caused by infection with human herpesvirus 8 and occurs in four settings: classic KS, African (endemic) KS, immunosuppressive-associated KS, and AIDS-associated KS. The…

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