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A Clinical Atlas of 101 Common Skin Diseases

Alopecias

Loss of hair attributable either to the effects of inflammatory cells on follicles or to physiological or mechanical factors in which inflammatory cells play no role. Although the scalp is the site most often affected, any region of the skin that be…

A Clinical Atlas of 101 Common Skin Diseases

Verrucae

Papules on skin and mucous membranes that result from infection of keratinocytes by different types of papillomavirus and classified according to their silhouettes, to wit, papillated (verrucae vulgares on different sites such as volar skin, i.e., v…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…ermal junction by lymphocytes, jagged acanthosis, wedge-shaped hypergranulosis, and compact orthokeratosis = Lichen planus, early Zones of wedge-shaped hypergranulosis are centered around acrosyringia and the upper part of infundibula. 10.60.2A…

Histologic Diagnosis of Inflammatory Skin Diseases

Lichen planus

…vidual necrotic keratocytes Jagged acanthosis and wedge-shaped hypergranulosis Cornified layer mostly basket-weave, but compact orthokeratosis especially above foci of hypergranulosis Fully developed Superficial perivascular infiltrate of lymphocyt…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.23.1A: Perivascular dermatitis, psoriasiform + 10.23.1B: Orthokeratosis, hypergranulosis, acanthosis, proliferation of infundibular and eccrine ductal keratocytes, and coarse bundles of collagen in vertical streaks = Lichen simp…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 11.11.1A: Perivascular dermatosis, lichenoid + 11.11.1B: Lymphocytes, many necrotic keratocytes and a subepidermal cleft = Lichen planus-like keratosis, earlyBecause lichen planus-like keratosis often is misinterpreted…

Histologic Diagnosis of Inflammatory Skin Diseases

Applicable Terms

…yaline-containing keratocytes in infundibula and acrosyringia. Hypergranulosis is a finding, consistently, in a variety of conditions as unlike as lichen simplex chronicus and bullous congenital ichthyosiform erythroderma. As a rule, hypergranulosis

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…ermal junction, necrotic keratocytes throughout the epidermis, hypergranulosis, and orthokeratosis = Graft-versus-host disease The hyperkeratosis and hypergranulosis permit this lesion of graft-versus-host disease to be differentiated from erythema m…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Perivascular Dermatitis

See Figs. 5.16 A&B, 5.17 A&B, 5.18 A&B, 5.19 A&B, 5.20 A&B, 5.21 A&B, and 5.22 A&B Figure 5.16 A. Perivascular dermatitis, perivascular only, superficial. B. Perivascular dermatitis, perivascular only, superficial and…

Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

…-host disease/eruption of lymphocyte recovery + Wedge-shaped hypergranulosis and jagged acanthosis = Lichen planus + Focal parakeratosis, focal hypergranulosis, lymphocytes along the dermoepidermal interface, and lichenoid infiltrate of lymphocyt…

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