Histologic Diagnosis of Inflammatory Skin Diseases

Lichen planus

…ishing. Lichen planus-like keratosis: Focal parakeratosis and hypogranulosis, abundant elastotic material in the dermis, and, often, findings of residual solar lentigo are differentiating. Peri-infundibular and perifollicular accentuation of classic…

Histologic Diagnosis of Inflammatory Skin Diseases

Lichen planus-like keratosis

…which the epidermis is thin Hypergranulosis in some foci and hypogranulosis in others Ortho- and parakeratosis to variable extent Residual solar lentigo obscured partially by infiltrates of lymphocytes or present, undisguised, usually at the periphe…

Histologic Diagnosis of Inflammatory Skin Diseases

Applicable Terms

…a basket-weave pattern. Figure 3.19 A. Hypergranulosis. B. Hypogranulosis. HYPERKERATOSIS [Gk. hyper (above) + keratos (horn) + -osis (condition)]: A thickened cornified layer of an epithelium, usually an epidermis (surface and infundibular), but…

Histologic Diagnosis of Inflammatory Skin Diseases

Pityriasis rubra pilaris

…ermal basal layer Granular layer mostly preserved, but slight hypogranulosis in foci Alternation of orthokeratosis and parakeratosis in a pattern that resembles vaguely a checkerboard Infundibula dilated and plugged by orthokeratotic and parakeratoti…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Follicular Degeneration Syndrome?

…play thin, elongated rete ridges, thin suprapapillary plates, hypogranulosis, and a normal cornified layer. LoPresti et al. believed that a burn by the hot petrolatum was responsible for the alopecia. The findings histopathologic in hot-comb alopecia…

Histologic Diagnosis of Inflammatory Skin Diseases

Psoriasis

…form and subcorneal pustules in the epidermis of some lesions Hypogranulosis in some foci Mounds of parakeratosis with neutrophils at their summit staggered in the stratum corneum, sometimes beneath the retained original cornified layer with its bask…

Differential Diagnosis in Dermatopathology

Discussions

…ny necrotic keratocytes in a focally thinned epidermis, focal hypogranulosis, and parakeratosis Lichenoid discoid lupus erythematosus in which the epidermal basement membrane often is thickened markedly The lichenoid expression of persistent pigm…

Differential Diagnosis in Dermatopathology

Discussions

…focally. In loci, there may be zones of epidermal atrophy and hypogranulosis. The epidermis assumes a pink cast as a consequence of premature cornification of keratocytes, which often is evidenced, too, by dyskeratotic cells. Atypical keratocytes and…