Histologic Diagnosis of Inflammatory Skin Diseases

Incontinentia pigmenti

Incontinentia pigmenti Synonyms Bloch-Sulzberger syndrome Presentation stereotypical Age and sex Lesions in females at birth. Practically never in boys. Distribution of lesions Trunk and extremities Arrangement of lesions Linear, streaks, and whorls…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…in association with numerous individual necrotic keratocytes = Incontinentia pigmenti, verrucous stage, incipient The changes shown represent a phase of transition between the vesicular stage and the verrucous stage of incontinentia pigmenti, those s…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Vesicular Dermatitis

…ure 5.254 A&B. Spongiotic vesicle mediated by eosinophils: incontinentia pigmenti. The tense multiloculated vesicle of incontinentia pigmenti pictured here began with spongiosis brought about by eosinophils that now are present in number within t…

Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

…e. + Large collections of eosinophils in spongiotic vesicles = Incontinentia pigmenti + Collections of eosinophils in discrete loci of the epidermis = Toxic erythema of the newborn + Acantholytic cells in suprabasal spaces, surface epidermal and…

Histologic Diagnosis of Inflammatory Skin Diseases

Applicable Terms

…ses, such as Grover’s disease and the verrucous stage of incontinentia pigmenti; in neoplastic diseases, such as Bowen’s disease and subungual keratoacanthoma; in genodermatoses such as Darier’s disease; and in cystic conditions suc…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Blaschkitis?

…heterozygous states of various X-linked gene defects, such as incontinentia pigmenti, X-linked hypohidrotic ectodermal dysplasia, and focal dermal hypoplasia. For Happle it is evident that a direct relationship exists between lyonization and the lin…

Histologic Diagnosis of Inflammatory Skin Diseases

Herpes gestationis

…us vulgaris, dermatitis herpetiformis, cicatricial pemphigoid, incontinential pigmenti, urtica, an insect “bite,” and urticarial papules and plaques of pregnancy are different from one another and from urticarial lesions of bullous pemphi…