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Therapeutic Strategies in Dermatology

Lupus: Key Points

…interface dermatitis, often in association with a lymphocytic infiltrate with plasma cells, epidermal atrophy, and mucin. Variants exist, such as bullous lupus, which is marked by the presence of bullous lesions clinically and histologically, the in…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Perivascular Dermatitis

…dermis, is both superficial and deep, but in this example, the infiltrate is superficial only. Figure 5.24 A. Perivascular dermatitis, superficial and deep (slight deep). B&C. Allergic contact dermatitis. As a rule, the infiltrate of lymphocyt…

Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

…Ruptured molluscum contagiosum + Perivascular and/or nodular infiltrate of lymphocytes and histiocytes in the dermis and subcutaneous tissue, the macrophages containing nuclear debris = Kikuchi”s disease + Sparse superficial perivascular in…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Nodular and Diffuse Dermatitis

…cular dermatitis (see Fig. 5.16 A&B) by the density of the infiltrate of inflammatory cells. In the perivascular dermatitides, the infiltrates can be described roughly as being sparse to moderately dense, whereas in nodular dermatitides the infil…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…tic and ballooned + 10.5.2B: Perivascular and interstitial infiltrate replete with eosinophils = Response to an insect “bite” A tense intraepidermal vesicle above a wedge-shaped, superficial and deep perivascular and interstitial infi…

Histologic Diagnosis of Inflammatory Skin Diseases

Lichen planus

…nus. Findings histopathologic Early Superficial perivascular infiltrate of lymphocytes Lichenoid infiltrate of lymphocytes, patchy at first and then confluent Infiltrate obscures the dermoepidermal junction in conjunction with vacuolar alteration a…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…hils = Lymphomatoid papulosis ¬†Episodically, as shown here, an infiltrate of lymphomatoid papulosis is distributed mostly in peri-infundibular fashion. Despite its sparseness, the infiltrate can be told to be that of lymphomatoid papulosis because of…

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