Histologic Diagnosis of Inflammatory Skin Diseases

Predominantly Intraepithelial Fluorescence

Intraepithelial, in this context, usually is synonymous with intraepidermal, both surface and infundibular, although in some instances, particularly pemphigus vulgaris, adnexal epithelium also may be affected. The prototype for intraepithelial fluor…

Therapeutic Strategies in Dermatology

Non-Melanoma Skin Cancers (NMSC): Basal Cell Carcinoma (BCC) and Squamous Cell Carcinoma (SCC): Non-Melanoma Skin Cancers (NMSC): Basal Cell Carcinoma (BCC) and Squamous Cell Carcinoma (SCC) – Initial Evaluation–Bowen’s Disease (Squamous Cell Carcinoma in Situ) – genprac

…n, and on the glans penis (erythroplasia of Queyrat or penile intraepithelial neoplasia [PIN]). Actinically induced lesions are considered a step in the progression of actinic keratoses to squamous cell carcinoma. Erythematous, hyperkeratotic plaque…

Therapeutic Strategies in Dermatology

Erythema Multiforme: Treatment

…d or treated. Diagnostic considerations include: viral direct fluorescence antibody (DFA) testing, viral culture, herpes serologies, mycoplasma serologies or cold agglutinins, and chest X-ray. For bullous skin lesions, aluminum acetate compresses (s…

Therapeutic Strategies in Dermatology

Herpes Zoster & Varicella: Treatment

…etic neuralgia. Confirmation of herpes zoster by viral direct fluorescence assay (DFA) is recommended in most cases, especially in disseminated cases or cases involving immunocompromised or pregnant patients. Contact and respiratory isolation may be…

Histologic Diagnosis of Inflammatory Skin Diseases

Predominantly Basement Membrane Zone Fluorescence

…r the vast majority of the diseases diagnosed by direct immunofluorescence. Fluorescence at the basement membrane zone may be fine and discretely linear, thick and somewhat glassy linear, or granular. At times, the “boundaries” between th…

Histologic Diagnosis of Inflammatory Skin Diseases

Predominantly Vascular/Perivascular Fluorescence

In general, fluorescence in and around vessels is thought to be synonymous with vasculitis of small blood vessels, that is, postcapillary venules. In reality, however, vasculitis is not a diagnosis that should be made principally on the basis of fin…

A Clinical Atlas of 101 Common Skin Diseases

Amyloidosis

A condition in which deposits of a fibrillary protein (amyloid) appear in the skin as macules, papules, and nodules consequent to the effects of local factors, or as patches (which may be purpuric), plaques, nodules, and tumors as a result of a syst…

A Clinical Atlas of 101 Common Skin Diseases

Porphyria Cutanea Tarda

A disease manifested chiefly in the skin by vesicles and bullae that appear on sites of trauma, especially the face and dorsa of the hands, often in conjunction with macular hyperpigmentation and hypertrichosis of a face and sclerodermoid changes on…