Histologic Diagnosis of Inflammatory Skin Diseases

Predominantly Intraepithelial Fluorescence

Intraepithelial, in this context, usually is synonymous with intraepidermal, both surface and infundibular, although in some instances, particularly pemphigus vulgaris, adnexal epithelium also may be affected. The prototype for intraepithelial fluor…

Therapeutic Strategies in Dermatology

Erythema Multiforme: Treatment

Treatment Initial therapy First-line treatment is supportive care. Diagnostic management should entail consideration of a skin biopsy and a reasonable search for potential triggers that can be eliminated or treated. Diagnostic considerations inclu…

Therapeutic Strategies in Dermatology

Herpes Zoster & Varicella: Treatment

Treatment Herpes zoster First-line therapy: The first-line therapy for herpes zoster includes the treatment of the acute eruption and therapy for herpetic neuralgia and post-herpetic neuralgia. Confirmation of herpes zoster by viral direct fluoresc…

Histologic Diagnosis of Inflammatory Skin Diseases

Predominantly Basement Membrane Zone Fluorescence

…, in actuality, it fundamentally is a linear process. Although fluorescence at the basement membrane zone may be finely linear, thick and glassy linear, or granular, the most common of them is finely linear (Fig. 8.3). If the fine linear fluorescence

Histologic Diagnosis of Inflammatory Skin Diseases

Predominantly Vascular/Perivascular Fluorescence

…of the superficial plexus. The only other pattern of vascular fluorescence that deserves mention is the already-described thick, smooth, perivascular one (for IgG and often IgA) that occurs in conjunction with a similar pattern of fluorescence at th…

Therapeutic Strategies in Dermatology

Non-Melanoma Skin Cancers (NMSC): Basal Cell Carcinoma (BCC) and Squamous Cell Carcinoma (SCC): Non-Melanoma Skin Cancers (NMSC): Basal Cell Carcinoma (BCC) and Squamous Cell Carcinoma (SCC) – Initial Evaluation–Bowen’s Disease (Squamous Cell Carcinoma in Situ) – genprac

Initial Evaluation: Bowen’s Disease (Squamous Cell Carcinoma in Situ) The eponym BowenÂ’s disease is used to describe squamous cell carcinoma in situ on any cutaneous surface except the glans penis. It bears several clinical features: Untreate…

A Clinical Atlas of 101 Common Skin Diseases

Porphyria Cutanea Tarda

A disease manifested chiefly in the skin by vesicles and bullae that appear on sites of trauma, especially the face and dorsa of the hands, often in conjunction with macular hyperpigmentation and hypertrichosis of a face and sclerodermoid changes on…

A Clinical Atlas of 101 Common Skin Diseases

Amyloidosis

A condition in which deposits of a fibrillary protein (amyloid) appear in the skin as macules, papules, and nodules consequent to the effects of local factors, or as patches (which may be purpuric), plaques, nodules, and tumors as a result of a syst…