Histologic Diagnosis of Inflammatory Skin Diseases

Applicable Terms

…the seven basic patterns of inflammatory disease in the skin. KARYOLYSIS [Gk. karyon (nut) + lysis (to loosen)]: Disappearance of nuclei from cells during the process of cell death. Karyolysis (ghosts of nuclei), karyorrhexis (fragmentation of nuclei…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…e same stimulus. Signs of epidermal necrosis are pyknosis and karyolysis. 10.23.8A: Perivascular dermatitis, psoriasiform, eroded and ulcerated + 10.23.8B: Hyperkeratosis, proliferation of keratocytes of surface and infundibular epidermis,…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Apoptosis?

…tic nuclei), karyorrhexis (“dust” of nuclei), and karyolysis (ghosts of nuclei). So-called apoptotic cells show two of the three signs of necrosis, namely, pyknosis and karyorrhexis. Moreover, the cytoplasm of apoptotic cells is eosinophi…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Subcutaneous Fat: Panniculitis

…nctive changes in nuclei, namely, pyknosis, karyorrhexis, and karyolysis, are indicators essential of necrosis. In fat lobules, however, most nuclei are missed as a microtome slices through rotund adipocytes, and, that being the case, they are not av…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Vesicular Dermatitis

…cells are doomed to die, the telltale sign of necrosis being karyolysis and cytoplasm of an eosinophilic cast. Acantholytic cells appear, too, in the spinous, granular, and cornified layers of diseases typified by formation of suprabasal clefts, rat…

Histologic Diagnosis of Inflammatory Skin Diseases

Errors and Reasons

…logically by three signs, namely, pyknosis, karyorrhexis, and karyolysis; apoptosis is typified by pyknosis and karyorrhexis, and, therefore, logic compels that it fulfills criteria for necrosis. Error: Apocrine miliaria is an analogue of eccrine mil…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Perivascular Dermatitis

…is in the upper part of the epidermis. Necrosis, evidenced by karyolysis especially, in the upper half of the viable epidermis is a result of external injury, in this instance in the form of scratching furiously, so uncontrollably that an ulcer, seen…

Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

…An epidermis that exhibits nuclei characterized mostly by karyolysis and cytoplasm typified by eosinophilia across a front of at least several millimeters. Click image to enlarge. + Lymphocytes and vacuolar alteration along the dermoepidermal int…