Histologic Diagnosis of Inflammatory Skin Diseases

Applicable Terms

…ing the process of cell death. Karyolysis (ghosts of nuclei), karyorrhexis (fragmentation of nuclei), and pyknosis (shrinkage and darkening of nuclei) are the three cardinal signs of necrosis (Fig. 3.21B). Karyolysis may be observed whenever necrosis…

Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

…es Necrotic keratocytes, characterized by pyknosis and karyorrhexis, disposed as solitary units in an epidermis and sometimes in eccrine ducts. Many synonyms have been given to them, among those being “Civatte bodies,” “collo…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Apoptosis?

…s nuclear, namely, pyknosis (shrunken hyperchromatic nuclei), karyorrhexis (“dust” of nuclei), and karyolysis (ghosts of nuclei). So-called apoptotic cells show two of the three signs of necrosis, namely, pyknosis and karyorrhexis. Moreov…

Histologic Diagnosis of Inflammatory Skin Diseases

Errors and Reasons

…cterized cytopathologically by three signs, namely, pyknosis, karyorrhexis, and karyolysis; apoptosis is typified by pyknosis and karyorrhexis, and, therefore, logic compels that it fulfills criteria for necrosis. Error: Apocrine miliaria is an analo…

Histologic Diagnosis of Inflammatory Skin Diseases

Confusing Terms (to be Avoided Scrupulously)

…ogen). The keratocytes so affected show signs of pyknosis and karyorrhexis, evidence of necrosis. An example of apoptosis, as it is purported to occur histopathologically, is Civatte bodies (colloid bodies, hyaline bodies) in lichen planus, the kerat…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Perivascular Dermatitis

…tic cells”; apoptosis, typified as it is by pyknosis and karyorrhexis, fulfills criteria for necrosis. Utilizing the five essential patterns of perivascular dermatitis and subdivisions of them, the following algorithm can be constructed:…