Histologic Diagnosis of Inflammatory Skin Diseases

Applicable Terms

…lysosomes. Figure 3.21 A. Normal nucleus. B. Karyolysis. C. Karyorrhexis. D. Pyknosis. KARYORRHEXIS [Gk. karyon (nut) + rhegsis (to burst)]: Dot-like debris of nuclei, known also as nuclear “dust” (Fig. 3.21C), one of a triad of pivota…

Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

In this section, algorithms used to reach specific diagnosis are predicated on “nonspecific” findings recognized best at higher magnification. Other changes requisite for specific diagnoses, i.e., denominators that are essential, then are added to a particular “nonspecific” finding, beginning with those attributes discernable at moderately high magnification and processing to those visualizable at progressively lower […]

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Apoptosis?

…gs nuclear, namely, pyknosis (shrunken hyperchromatic nuclei), karyorrhexis (“dust” of nuclei), and karyolysis (ghosts of nuclei). So-called apoptotic cells show two of the three signs of necrosis, namely, pyknosis and karyorrhexis. Moreo…

Histologic Diagnosis of Inflammatory Skin Diseases

Errors and Reasons

…acterized cytopathologically by three signs, namely, pyknosis, karyorrhexis, and karyolysis; apoptosis is typified by pyknosis and karyorrhexis, and, therefore, logic compels that it fulfills criteria for necrosis. Error: Apocrine miliaria is an anal…

Histologic Diagnosis of Inflammatory Skin Diseases

Confusing Terms (to be Avoided Scrupulously)

APOPTOSIS [Gk. apo- (away from) + ptosis (a falling)]: Reputed to be a specific type of cell death in which dead cells are said to undergo fragmentation by implosion with subsequent phagocytosis of nuclear debris (Fig. 3.40). The process is claimed…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Perivascular Dermatitis

See Figs. 5.16 A&B, 5.17 A&B, 5.18 A&B, 5.19 A&B, 5.20 A&B, 5.21 A&B, and 5.22 A&B Figure 5.16 A. Perivascular dermatitis, perivascular only, superficial. B. Perivascular dermatitis, perivascular only, superficial and…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Nodular and Diffuse Dermatitis

See Fig. 5.174 A&B. Figure 5.174 A&B. Nodular dermatitis and diffuse dermatitis. Nodular dermatitis is distinguished from perivascular dermatitis (see Fig. 5.16 A&B) by the density of the infiltrate of inflammatory cells. In the periv…