Histologic Diagnosis of Inflammatory Skin Diseases

Dermatomyositis

…ion with subtle vacuolar alteration and an occasional necrotic keratocyte Mucin increased slightly in the reticular dermis Venules of the superficial plexus dilated Epidermis slightly thinned focally Nuclei of keratocytes of thinned epidermis sometim…

Histologic Diagnosis of Inflammatory Skin Diseases

Melanocytes

…yte is smaller and more deeply basophilic than that of a basal keratocyte, and the cytoplasm of it is dendritic, unlike that of a keratocyte (Fig. 1.63). Dendrites of melanocytes are revealed more effectively with silver salts that stain melanin blac…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.2.1A: Perivascular dermatitis, spongiotic and slightly psoriasiform + 10.2.1B: Slight edema of the papillary dermis and scale-crust = Nummular dermatitis ┬áChanges such as these are indistinguishable from those of allergic contac…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Perivascular Dermatitis

…acuolar” or “lichenoid,” individual necrotic keratocytes, sometimes few and at other times numerous in the epidermal basal layer or just above it, often are accompaniments (Fig. 5.56 A&B). Episodically, clusters of necrotic kera…

Histologic Diagnosis of Inflammatory Skin Diseases

Applicable Terms

…junction with complement that resides on epidermal and adnexal keratocytes in pemphigus vulgaris and pemphigus foliaceus; (2) neutrophils on keratocytes in the lower part of the epidermis of subepidermal vesicular dermatitides, such as dermatitis her…

Histologic Diagnosis of Inflammatory Skin Diseases

Cells That Mediate Inflammation (Inflammatory Cells)

…anergic leishmaniasis. During the course of many dermatitides, keratocytes may express MHC class II molecules in response to release by activated lymphocytes of IFN-gamma, an indication that, in a generic sense, keratocytes, like endothelial cell, co…

Histologic Diagnosis of Inflammatory Skin Diseases

Dermoepithelial Interface

…skeleton, that is, hemidesmosomes and plasma membrane of basal keratocytes that constitute the upper boundary of the interface; (2) the lamina lucida, an electron-lucent region that lies beneath basal keratocytes; (3) the lamina densa, an electron-de…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…l junction and in the spinous zone, and ballooned and necrotic keratocytes = Mucha-Habermann disease, acute That this lesion is recent in onset may be inferred from the presence of an entirely normal cornified layer, ballooned keratocytes, many indiv…