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A Clinical Atlas of 101 Common Skin Diseases

Histiocytosis X

A proliferation of abnormal Langerhanscells that may affect internal organs, e.g., the spleen, liver, and bone, sometimes with fatal outcome, as well as the skin, where lesions usually manifest themselves as purpuric papules or ulcers that m…

Therapeutic Strategies in Dermatology

Histiocytosis X/Langerhans Cell Histiocytoses: Overview

Overview Langerhans cell histiocytoses (Class I histiocytosis) are a group of disorders most common in childhood due to the accumulation or proliferation of a clonal population of cells bearing the phenotype of a Langerhans cell that has been arrest…

Therapeutic Strategies in Dermatology

Oral Hairy Leukoplakia: Key Points

…an transplant recipients. Increased numbers of EBV-infected B cells and reduced numbers of EBV-specific cytotoxic T cells noted in biopsies of OHL, in addition to the absence or reduced number of Langerhans cells, suggest key immunologic factors asso…

Histologic Diagnosis of Inflammatory Skin Diseases

Cells That Mediate Inflammation (Inflammatory Cells)

…ells, lymphocytes in particular. The term “inflammatory cells” is understood as being generic for neutrophils, eosinophils, lymphocytes, plasma cells, and histiocytes; whether mast cells, basophils, Langerhanscells, dermal dendroc…

Histologic Diagnosis of Inflammatory Skin Diseases

Langerhans’ Cells

Langerhanscells, named for Paul Langerhans who, while a medical student in Berlin in 1868, was the first to describe them, are dendritic cells that reside just above the middle of the spinous zone of the epidermis. They make their appearance…

Dermatology Practical & Conceptual

Epidermal multinucleated giant cells are not always a histopathologic clue to a herpes virus infection: multinucleated epithelial giant cells in the epidermis of lesional skin biopsies from patients with acantholytic dermatoses can histologically mimic a herpes virus infection

Abstract Background: Multinucleated giant cells in the epidermis can either be epithelial or histiocytic. Epithelial multinucleated giant cells are most often associated with herpes virus infections. Purpose: To review the histologic differential di…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Langerhans’ Cell Granulomatosis?

…for instance, in HX) but this would imply that intraepidermal Langerhanscells [LC] or LC in the dermis represent pathologic, or at least, not “normal” cells, which is difficult to accept. If, on the other hand, the LC is considere…

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