Histologic Diagnosis of Inflammatory Skin Diseases

Applicable Terms

…necrotic. A synonym for karyorrhexis of white blood cells is leukocytoclasis, as is seen in leukocytoclastic vasculitis and in a host of other conditions as unrelated to one another as Sweet’s syndrome and bullous lupus erythematosus. Because…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Vasculitis

…asculitis, as the name of that pathologic process denotes, is leukocytoclasis in an infiltrate made up mostly of neutrophils (Fig. 5.221 A&B); the denominator in common for diagnosis histopathologic of septic vasculitis is presence of thrombi in…

Histologic Diagnosis of Inflammatory Skin Diseases

Leukocytoclastic vasculitis

…ibrin in the wall of venules. Urtica never is associated with leukocytoclasis of neutrophils. Clue to specific diagnosis histopathologic Nuclear “dust” of neutrophils in the interstitium of the upper part of the reticular dermis in the a…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Subcorneal Pustular Dermatosis?

…l diagnostic difficulties. Systemic symptoms (fever, malaise, leukocytoclasis), the presence of spongiform pustules within the epidermis, and the failure of pustular psoriasis to respond to sulfones represent reliable criteria to distinguish it from…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Subcutaneous Fat: Panniculitis

…mall-vessel vasculitis in the subcutaneous fat accompanied by leukocytoclasis of neutrophils, no matter how minute the amount of nuclear “dust,” is leukocytoclastic vasculitis (see Fig. 5.233), a condition joined often by eosinophils. Thr…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Urticarial Vasculitis?

…ophils and residua of them, i.e., nuclear “dust” (leukocytoclasis). Nearly always, erythrocytes are extravasated among the inflammatory cells. Fibrin, however, is not present in the wall of venules in the urticarial stage of leukocytoclas…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…inflammatory cells, makes this a vasculitis; the presence of leukocytoclasis makes it leukocytoclastic vasculitis. 10.58.20A: Vasculitis, small-vessel, neutrophilic + 10.58.20B: Neutrophils, nuclear “dust” of neutrophils, extra…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…in the lumen of some small vessels, degeneration of collagen, leukocytoclasis, and confluent epidermal necrosis = Response to the “bite” of a spider This dermatitis in the form of perivascular and interstitial mixed-cell infiltrates, smal…