Therapeutic Strategies in Dermatology

Erysipelas/Cellulitis: Key Points

Key Points Erysipelas and cellulitis are infections of the dermis and subcutaneous layers of the skin that are rapidly progressive and are often accompanied by systemic signs, such as fever, leukocytosis, and elevated markers of systemic inflammat…

Histologic Diagnosis of Inflammatory Skin Diseases

Lymphatics

The skin is home to an elaborate network of lymphatic vessels that parallels the major blood vascular plexuses but is independent of them. From a superficial plexus of lymphatic capillaries arise progressively thicker-walled lymphatic vessels whose…

A Clinical Atlas of 101 Common Skin Diseases

Melanoma

A malignant neoplasm of melanocytes that, in the skin, begins as a macule and may become a patch or a papule. A flat lesion of melanoma tends to be asymmetrical, poorly circumscribed with a scalloped, jagged, or notched border, and variegate, mostly…

A Clinical Atlas of 101 Common Skin Diseases

Deep Fungal Infections

Cutaneous and subcutaneous lesions, usually nodules, that have become keratotic, crusted, and ulcerated as a consequence of infection by a variety of deep fungi, i.e., fungi situated in the dermis and subcutis, some of which may be disseminated to o…

Histologic Diagnosis of Inflammatory Skin Diseases

Lymphedema

…rimary lymphedema is hereditary and is the result of defective lymphatics, i.e., hypoplastic vessels. Obstruction or infiltration of lymphatics leads to stasis of lymph, as in metastasis to lymph nodes, fibrosis after multiple bouts of lymphangitis/l…

Dermatology Practical & Conceptual

From the Dermatologikum Hamburg: Quiz

…roversy whether it can be differentiated from blood vessels or lymphatics and whether it is a true neoplasm or a malformation. Franke et al, in 2004, showed that endothelia of hobnail hemangiomas exhibit an antigenic profile similar to normal lymphat…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 11.12.1A: Fibrosing dermatitis + 11.12.1B: Widely dilated lymphatics in company with an increased number of thick-walled blood vessels lined by plump endothelial cells, those vessels in the upper part of the dermis being oriented m…

Histologic Diagnosis of Inflammatory Skin Diseases

Cells That Mediate Inflammation (Inflammatory Cells)

Neutrophils, eosinophils, lymphocytes, plasma cells, and histiocytes are called inflammatory cells because they enter tissue during the process of inflammation. A more exact designation for them is “cells of an inflammatory process”; the…

Histologic Diagnosis of Inflammatory Skin Diseases

Erysipelas

Erysipelas Synonyms St. Anthony’s fire Ignis sacer Erysipele Erysipela Presentation stereotypical Age and sex Any age and either sex, but with a predilection for older persons with diabetes, peripheral vascular disease, and abuse of alcohol…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Satellite, in Transit, Regional, and Distant Metastases?

“Satellites can be defined as cutaneous metastases of melanoma occurring within the reticular dermis or subcutis at a distance of less than 5 cm from the primary tumour.” Mooi WJ, Krausz T. Prognostic factors in cutaneous melanoma. In:…