Therapeutic Strategies in Dermatology

Venous Stasis: Treatment

…ridement will accelerate healing. Apply 30% lidocaine in acid mantle base and wait 20 minutes before gently debriding with a curette. This can be repeated at each clinic visit until all necrotic debris has been removed from the ulcer bed. Daily wound…

Histologic Diagnosis of Inflammatory Skin Diseases

Sebaceous Units

…erentiated cells disposed in cords that hang like a cloak, or mantle, along the sides of both vellus and terminal follicles (Fig. 1.44). A mantle is continuous with an infundibulofollicular structure, originating at the junction of an infundibulum an…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Trichodiscoma Related to the Hair Disk and Merkel-Cell Neoplasm to Merkel Cells?

…rofolliculoma,” a hamartoma of the hair follicle and of mantles of follicles in particular. Mantles, also described first by Felix Pinkus, emerge from the junction of the infundibulum and isthmus and, in sections cut vertically, are seen to han…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Tricho-, pilo-, folliculo- ?

…fibrofolliculoma, the condition actually is an abnormality of mantles of a follicle, those distinctive cords of undifferentiated germinative epithelium that originate normally at the junction of infundibulum and isthmus and that droop along the folli…

Histologic Diagnosis of Inflammatory Skin Diseases

Cells That Mediate Inflammation (Inflammatory Cells)

…by epithelioid histiocytes derives from the lack of a notable mantle of lymphocytes (and sometimes plasma cells) around the granulomas and from absence of caseous necrosis. For this reason, sarcoidal granulomas have been considered to be different, m…

Histologic Diagnosis of Inflammatory Skin Diseases

Applicable Terms

…“naked” tubercle), and that surrounded by a dense mantle of lymphocytes, and sometimes plasma cells, is designated tuberculoid. Sarcoidal granulomas are found not only in sarcoidosis, but also in foreign body responses to materials such a…

Histologic Diagnosis of Inflammatory Skin Diseases

Cat-scratch disease

…rin in the upper part of the reticular dermis surrounded by a mantle of macrophages, lymphocytes, and plasma cells Granulomas of stellate shape often joined by neutrophils in number in the center of them (“stellate abscess”) Extensive pro…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…. Lymphoid follicles abnormal and poorly circumscribed 6. A mantle of lymphocytes around germinal centers usually well defined 6. No well-defined mantle of lymphocytes around germinal centers as a rule 7. Atypical lymphocytes few; never do they p…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Nodular and Diffuse Dermatitis

…l” (Fig. 5.187), and when a granuloma is encircled by a mantle of lymphocytes (and sometimes plasma cells), it is deemed to be “tuberculoid” (Fig. 5.188). A granuloma in which epithelioid histiocytes are arranged in the manner of a…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…fashion than usual. Lymphocytes and plasma cells comprise the mantle that surrounds structures that resemble germinal centers. 10.68.3A: Nodular and interstitial dermatitis, histiocytes predominate, and panniculitis, lobular + 10.68.3B: Man…