Therapeutic Strategies in Dermatology

Venous Stasis: Treatment

Treatment Stasis dermatitis First-line therapy: The first-line therapy for stasis dermatitis includes control of edema, if possible, and use of an anti-inflammatory topical medication such as a medium potency topical corticosteroid. Stasis dermati…

Histologic Diagnosis of Inflammatory Skin Diseases

Sebaceous Units

…ferentiated cells disposed in cords that hang like a cloak, or mantle, along the sides of both vellus and terminal follicles (Fig. 1.44). A mantle is continuous with an infundibulofollicular structure, originating at the junction of an infundibulum a…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Trichodiscoma Related to the Hair Disk and Merkel-Cell Neoplasm to Merkel Cells?

…brofolliculoma,” a hamartoma of the hair follicle and of mantles of follicles in particular. Mantles, also described first by Felix Pinkus, emerge from the junction of the infundibulum and isthmus and, in sections cut vertically, are seen to ha…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Tricho-, pilo-, folliculo- ?

…droop along the follicle for a short distance. They were named mantles by Felix Pinkus, who was among the first to describe them, because he thought they resembled cloaks, Mantle being the German word for cloak. When, however, mantles are viewed in c…

Histologic Diagnosis of Inflammatory Skin Diseases

Cells That Mediate Inflammation (Inflammatory Cells)

Neutrophils, eosinophils, lymphocytes, plasma cells, and histiocytes are called inflammatory cells because they enter tissue during the process of inflammation. A more exact designation for them is “cells of an inflammatory process”; the…

Histologic Diagnosis of Inflammatory Skin Diseases

Applicable Terms

ABSCESS [L. abscessus (a going away)]: Clinically, a circumscribed collection of pus and histopathologically a localized collection of neutrophils. An abscess may form in the epidermis, both surface and infundibular, eccrine ducts, dermis, and subcu…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Nodular and Diffuse Dermatitis

See Fig. 5.174 A&B. Figure 5.174 A&B. Nodular dermatitis and diffuse dermatitis. Nodular dermatitis is distinguished from perivascular dermatitis (see Fig. 5.16 A&B) by the density of the infiltrate of inflammatory cells. In the periv…

Histologic Diagnosis of Inflammatory Skin Diseases

Cat-scratch disease

Cat-scratch disease Presentation stereotypical Age and sex Any age and either sex, but children and young adults preponderantly Distribution of lesions Localized at the site of a scratch or a bite by a cat Individual lesions Papules, pustules, or cr…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.68.1A: Perivascular and interstitla dermatitis, and panniculitis, lobular + 10.68.1B: Histiocytes, many of them multinucleate, in palisaded array around foci of extensive degeneration of collagen and extracellular deposits of li…