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Therapeutic Strategies in Dermatology

Urticaria Pigmentosa / Mastocytosis: Key Points

…s, which may urticate when stroked. Patients with cutaneous mastocytosis may have a single isolated mastocytoma, diffuse cutaneous mastocytosis, urticaria pigmentosa, or a rare form of mast cells in the skin seen in adults characterized by telangie…

A Clinical Atlas of 101 Common Skin Diseases

Urticaria Pigmentosa

A benign neoplastic process of mast cells. In children the condition manifests itself as papules, nodules, and tumors that urticate upon rubbing, and as blisters; in adults it expresses itself as macules and papules accompanied by telangiectases (te…

Therapeutic Strategies in Dermatology

Urticaria: Initial Evaluation

…ction of auto-antibodies against the IgE receptor, triggering mast cell degranulation), or drug reaction. Whereas foods may be a relevant trigger for acute urticaria, the role of food allergies in chronic urticaria is controversial; a consistent, rep…

Therapeutic Strategies in Dermatology

Urticaria Pigmentosa / Mastocytosis: Treatment

Treatment First-line therapy: Avoiding triggers of mast cell degranulation. Patients should avoid extremes of temperature, particularly heat, and should be careful jumping into extremely hot baths or showers, cold swimming pools, or extremely cool a…

Histologic Diagnosis of Inflammatory Skin Diseases

Cells That Mediate Inflammation (Inflammatory Cells)

…ells, lymphocytes in particular. The term “inflammatory cells” is understood as being generic for neutrophils, eosinophils, lymphocytes, plasma cells, and histiocytes; whether mast cells, basophils, Langerhans” cells, dermal dendroc…

Dermatology Practical & Conceptual

Epidermal multinucleated giant cells are not always a histopathologic clue to a herpes virus infection: multinucleated epithelial giant cells in the epidermis of lesional skin biopsies from patients with acantholytic dermatoses can histologically mimic a herpes virus infection

Abstract Background: Multinucleated giant cells in the epidermis can either be epithelial or histiocytic. Epithelial multinucleated giant cells are most often associated with herpes virus infections. Purpose: To review the histologic differential di…

A Clinical Atlas of 101 Common Skin Diseases

Neurofibromatosis

…au lait “spots”) and of proliferations of Schwann cells (e.g., papules, nodules, and tumors of neurofibroma). The cutaneous lesions may be accompanied by neoplasms with neural differentiation that are situated in nerves (e.g., acoustic ne…

Therapeutic Strategies in Dermatology

Stings: Treatment

…inical picture of a local exaggerated reaction. Patients with mastocytosis may have severe, life-threatening reactions, which occur through both IgE- and non-IgE-mediated mechanisms and do not always represent true anaphylaxis. Non-IgE-mediated react…

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