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Therapeutic Strategies in Dermatology

Urticaria Pigmentosa/ Mastocytosis: Overview

…ent. Apply a superpotent topical steroid with occlusion to the mastocytoma nightly. Response is usually noted at about 3 weeks. If this does not reduce the number of mast cells sufficiently, try intralesional triamcinolone 5 mg/cc to the lesion. In a…

A Clinical Atlas of 101 Common Skin Diseases

Urticaria Pigmentosa

A benign neoplastic process of mast cells. In children the condition manifests itself as papules, nodules, and tumors that urticate upon rubbing, and as blisters; in adults it expresses itself as macules and papules accompanied by telangiectases (te…

Histologic Diagnosis of Inflammatory Skin Diseases

Cells That Mediate Inflammation (Inflammatory Cells)

cells, lymphocytes in particular. The term “inflammatory cells” is understood as being generic for neutrophils, eosinophils, lymphocytes, plasma cells, and histiocytes; whether mast cells, basophils, Langerhans” cells, dermal dendro…

Therapeutic Strategies in Dermatology

Urticaria: Initial Evaluation

Initial Evaluation Acute urticaria Migrating pruritic edematous papules and plaques of variable size, surrounded by erythema or an area of vasoconstriction (i.e., wheal). Can be intermittent, with the skin returning to normal appearance in less tha…

A Clinical Atlas of 101 Common Skin Diseases

Neurofibromatosis

A constellation of lesions that represent disorders of melanocytes (e.g., axillary "freckles" and café au lait "spots") and of proliferations of Schwann cells (e.g., papules, nodules, and tumors of neurofibroma). The cutan…

Therapeutic Strategies in Dermatology

Stings: Treatment

Treatment Local toxic reactions Initial therapy First-line therapy: Remove all embedded stingers (if present) as promptly as possible, as venom continues to be injected after the stinger is detached from the insect. Do not squeeze or pick up the s…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Benign and Malignant Cells?

…. Rather than trying to kll the highly dysplastic or malignant cells directly, a benign cell booster increases the fitness of the more benign cells, which may be either normal or benign clones, so that they may outcompete more advanced or malignant c…

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