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Therapeutic Strategies in Dermatology

Urticaria Pigmentosa / Mastocytosis: Key Points

…es, which¬†may urticate when stroked. Patients with cutaneous mastocytosis may have a single isolated mastocytoma, diffuse cutaneous mastocytosis, urticaria pigmentosa, or a rare form of mast cells in the skin seen in adults characterized by telangi…

A Clinical Atlas of 101 Common Skin Diseases

Urticaria Pigmentosa

A benign neoplastic process of mast cells. In children the condition manifests itself as papules, nodules, and tumors that urticate upon rubbing, and as blisters; in adults it expresses itself as macules and papules accompanied by telangiectases (te…

Histologic Diagnosis of Inflammatory Skin Diseases

Cells That Mediate Inflammation (Inflammatory Cells)

cells, lymphocytes in particular. The term “inflammatory cells” is understood as being generic for neutrophils, eosinophils, lymphocytes, plasma cells, and histiocytes; whether mast cells, basophils, Langerhans” cells, dermal dendro…

Therapeutic Strategies in Dermatology

Urticaria: Initial Evaluation

Initial Evaluation Acute urticaria Migrating pruritic edematous papules and plaques of variable size, surrounded by erythema or an area of vasoconstriction (i.e., wheal). Can be intermittent, with the skin returning to normal appearance in less tha…

Therapeutic Strategies in Dermatology

Urticaria Pigmentosa / Mastocytosis: Treatment

…ooms. Patients should avoid direct physical stimulation to the mastocytomas, and ideally anxiety and stress should be limited. First steps Avoid direct physical stimulation of mastocytoma lesions. Avoid hot temperatures or rapid temperature swings….

Dermatology Practical & Conceptual

Epidermal multinucleated giant cells are not always a histopathologic clue to a herpes virus infection: multinucleated epithelial giant cells in the epidermis of lesional skin biopsies from patients with acantholytic dermatoses can histologically mimic a herpes virus infection

Abstract Background: Multinucleated giant cells in the epidermis can either be epithelial or histiocytic. Epithelial multinucleated giant cells are most often associated with herpes virus infections. Purpose: To review the histologic differential di…

A Clinical Atlas of 101 Common Skin Diseases

Neurofibromatosis

A constellation of lesions that represent disorders of melanocytes (e.g., axillary "freckles" and café au lait "spots") and of proliferations of Schwann cells (e.g., papules, nodules, and tumors of neurofibroma). The cutaneous lesions may be accompanied by neoplasms with neural differentiation that are situated in nerves (e.g., acoustic neuroma) and in the brain (e.g., gliomas), […]

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