Search Results for: mast cells

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Therapeutic Strategies in Dermatology

Urticaria Pigmentosa / Mastocytosis: Key Points

mastocytosis may have a single isolated mastocytoma, diffuse cutaneous mastocytosis, urticaria pigmentosa, or a rare form of mast cells in the skin seen in adults characterized by telangiectasias and faint lesions, called telangiectasia macularis…

Therapeutic Strategies in Dermatology

Urticaria: Initial Evaluation

…fungal, parasitic, viral), autoimmune disease (including production of auto-antibodies against the IgE receptor, triggering mast cell degranulation), or drug reaction. Whereas foods may be a relevant trigger for acute urticaria, the role of food…

Therapeutic Strategies in Dermatology

Urticaria Pigmentosa / Mastocytosis: Treatment

…emic symptoms, abnormal blood counts, or elevated tryptase levels warrant more thorough investigation for potential systemic mastocytosis. Patients with cutaneous or systemic mastocytosis may be at risk of anaphylaxis. Patients with high burdens of…

Histologic Diagnosis of Inflammatory Skin Diseases

Cells That Mediate Inflammation (Inflammatory Cells)

…ells” is understood as being generic for neutrophils, eosinophils, lymphocytes, plasma cells, and histiocytes; whether mast cells, basophils, Langerhans” cells, dermal dendrocytes, fibrocytes, and platelets should be considered…

Epidermal multinucleated giant cells are not always a histopathologic clue to a herpes virus infection: multinucleated epithelial giant cells in the epidermis of lesional skin biopsies from patients with acantholytic dermatoses can histologically mimic a herpes virus infection

Epidermal multinucleated giant cells are not always a histopathologic clue to a herpes virus infection: multinucleated epithelial giant cells in the epidermis of lesional skin biopsies from patients with acantholytic dermatoses can histologically mimic a herpes virus infection

…Purpose: To review the histologic differential diagnosis of conditions with epithelial and histiocytic multinucleated giant cells—since multinucleated giant cells in the epidermis are not always pathognomonic of a cutaneous herpes virus…

Therapeutic Strategies in Dermatology

Stings: Treatment

…th IgE- and non-IgE-mediated mechanisms and do not always represent true anaphylaxis. Non-IgE-mediated reactions may reflect mast cell dysfunction. Patients with known mastocytosis should be prescribed auto-injectable epinephrine (such as an…

Therapeutic Strategies in Dermatology

Urticaria Pigmentosa / Mastocytosis: References

…t of a family and review of the role of KIT mutations. Am J Dermatopathol, 35, 113-116 Frieri M, Quershi M (2013). Pediatric mastocytosis: a review of the literature. Pediatr Allergy Immunol Pulmonol, 26, 175-180. Worobec AS (2000). Treatment of…

Therapeutic Strategies in Dermatology

Urticaria Pigmentosa / Mastocytosis: Clinical Case

…ures, particularly extreme heat Non-sedating H1 antihistamine trial initiated Counseled about signs and symptoms of systemic mastocytosis, including findings of vomiting, diarrhea, dyspnea, fatigue, or signs of systemic anaphylaxis Counseled about…

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