Search Results for: mastocytosis

Therapeutic Strategies in Dermatology

Urticaria Pigmentosa / Mastocytosis: Key Points

Key Points Mastocytosis can occur at any age, and may involve the skin, or affect internal organs including the bone marrow and liver/spleen/lymphatic tissues Urticaria pigmentosa is a form of cutaneous mastocytosis most common in childhood, charact…

Therapeutic Strategies in Dermatology

Urticaria Pigmentosa / Mastocytosis: Treatment

…VA) therapy can be effective in cases of widespread cutaneous mastocytosis. Many cases of childhood UP will self-resolve and fade away by puberty, and aggressive systemic therapy including cytoreductive therapy/chemotherapy is often unnecessary. Pitf…

Therapeutic Strategies in Dermatology

Urticaria Pigmentosa / Mastocytosis: References

…Current approaches to the diagnosis and treatment of systemic mastocytosis. Ann Allergy Asthma Immunol, 104, 1-10. Caplan RM (1963). The natural course of urticarial pigmentosa. Analysis and follow-up of 112 cases. Arch Dermatol, 87, 146-157. Castell…

Therapeutic Strategies in Dermatology

Stings: Treatment

…inical picture of a local exaggerated reaction. Patients with mastocytosis may have severe, life-threatening reactions, which occur through both IgE- and non-IgE-mediated mechanisms and do not always represent true anaphylaxis. Non-IgE-mediated react…

Therapeutic Strategies in Dermatology

Stings: Key Points

…der age, elevated serum tryptase level, cutaneous or systemic mastocytosis, and medications such as angiotensin-converting enzyme inhibitors. Vespid (wasp) stings are more commonly associated with anaphylactic reactions. Different hymenoptera members…

Therapeutic Strategies in Dermatology

Urticaria Pigmentosa / Mastocytosis: Clinical Case

…rial initiated Counseled about signs and symptoms of systemic mastocytosis, including findings of vomiting, diarrhea, dyspnea, fatigue, or signs of systemic anaphylaxis Counseled about mast cell degranulators and need to inform physicians and particu…

Therapeutic Strategies in Dermatology

Stings: References

References Rueff F et al (2011) Management of occupational hymenoptera allergy, Curr Opin Allergy Clin Immunol, 11(2): 69-74. Rueff F et al (2009) Stinging hymenoptera and mastocytosis, Curr Opin Allerg Clin Immunol, 9: 338-342….

Therapeutic Strategies in Dermatology

Flushing: Treatment

…ork-up. Urinary 5-HIAA is a good screen for pheochromocytoma. Mastocytosis can be diagnosed with serum tryptase and urine histamine levels. Other vasoactive substances are less common causes of flushing, and some could be identified with plasma catec…

Therapeutic Strategies in Dermatology

Flushing: Key Points

…etabolic disorders (e.g., carcinoid tumors, pheochromocytoma, mastocytosis, hormonal insufficiency states, brain tumors) or with the use of certain drugs; and finally, it can occur as a manifestation of rosacea. The pathophysiology of flushing is med…