Therapeutic Strategies in Dermatology

Urticaria Pigmentosa / Mastocytosis: Key Points

Key Points Mastocytosis can occur at any age, and may involve the skin, or affect internal organs including the bone marrow and liver/spleen/lymphatic tissues Urticaria pigmentosa is a form of cutaneous mastocytosis most common in childhood, char…

Therapeutic Strategies in Dermatology

Urticaria Pigmentosa / Mastocytosis: Treatment

…els warrant more thorough investigation for potential systemic mastocytosis. Patients with cutaneous or systemic mastocytosis may be at risk of anaphylaxis. Patients with high burdens of disease warrant consideration for prophylactic EpiPen prescript…

Therapeutic Strategies in Dermatology

Urticaria Pigmentosa / Mastocytosis: References

References Bains SN, Hsieh FH (2010). Current approaches to the diagnosis and treatment of systemic mastocytosis. Ann Allergy Asthma Immunol, 104, 1-10. Caplan RM (1963). The natural course of urticarial pigmentosa. Analysis and follow-up of 112 cas…

Therapeutic Strategies in Dermatology

Stings: Treatment

Treatment Local toxic reactions Initial therapy First-line therapy: Remove all embedded stingers (if present) as promptly as possible, as venom continues to be injected after the stinger is detached from the insect. Do not squeeze or pick up the s…

Therapeutic Strategies in Dermatology

Stings: Key Points

Key Points The order hymenoptera includes bees, wasps, hornets, and ants. Hymenoptera stings cause toxic and allergic reactions that present across a broad clinical spectrum: from mild, localized reactions to severe, systemic, and potentially fatal…

Therapeutic Strategies in Dermatology

Urticaria Pigmentosa / Mastocytosis: Clinical Case

Clinical Case Case 1 10-month-old healthy boy No significant past medical history Review of systems is noncontributory, notably negative for signs of fatigue, diarrhea, nausea, vomiting Social history is unremarkable Presents for evaluation o…

Therapeutic Strategies in Dermatology

Stings: References

References Rueff F et al (2011) Management of occupational hymenoptera allergy, Curr Opin Allergy Clin Immunol, 11(2): 69-74. Rueff F et al (2009) Stinging hymenoptera and mastocytosis, Curr Opin Allerg Clin Immunol, 9: 338-342….

Therapeutic Strategies in Dermatology

Flushing: Key Points

Key Points Flushing may be associated with a broad spectrum of underlying causes: medications, endocrine disease, neuroendocrine tumors, and neurologic diseases.  It is typically mediated by adrenergic hyperactivity, and only in rare cases is media…

Therapeutic Strategies in Dermatology

Flushing: Treatment

Treatment First-line therapy: The first-line therapy is to diagnose and treat the underlying cause, if present, and then attempt to control the flushing. If an underlying cause cannot be determined, or if flushing persists after treatment of the pri…