Search Results for: mastocytosis

Therapeutic Strategies in Dermatology

Urticaria Pigmentosa / Mastocytosis: Key Points

…tocytoma. Urticaria pigmentosa is most common in childhood, and less likely to have systemic involvement than adult forms of mastocytosis. Most patients develop mastocytosis in childhood, before the age of 2, with 60-80% of patients having lesions…

Therapeutic Strategies in Dermatology

Urticaria Pigmentosa / Mastocytosis: Treatment

…emic symptoms, abnormal blood counts, or elevated tryptase levels warrant more thorough investigation for potential systemic mastocytosis. Patients with cutaneous or systemic mastocytosis may be at risk of anaphylaxis. Patients with high burdens of…

Therapeutic Strategies in Dermatology

Urticaria Pigmentosa / Mastocytosis: References

…Dermatol, 87, 146-157. Castells M, Metcalfe DD, Escribano L (2011). Guidelines for the diagnosis and treatment of cutaneous mastocytosis in children. Am J Clin Dermatol 12, 259-270. Fett NM, Teng J, Longley BJ (2013). Familial urticarial…

Therapeutic Strategies in Dermatology

Stings: Treatment

…al bacterial infection (cellulitis) may closely simulate the clinical picture of a local exaggerated reaction. Patients with mastocytosis may have severe, life-threatening reactions, which occur through both IgE- and non-IgE-mediated mechanisms and…

Therapeutic Strategies in Dermatology

Stings: Key Points

…insects; other associated risk factors include male gender, older age, elevated serum tryptase level, cutaneous or systemic mastocytosis, and medications such as angiotensin-converting enzyme inhibitors. Vespid (wasp) stings are more commonly…

Therapeutic Strategies in Dermatology

Urticaria Pigmentosa / Mastocytosis: Clinical Case

…ures, particularly extreme heat Non-sedating H1 antihistamine trial initiated Counseled about signs and symptoms of systemic mastocytosis, including findings of vomiting, diarrhea, dyspnea, fatigue, or signs of systemic anaphylaxis Counseled about…

Therapeutic Strategies in Dermatology

Stings: References

References Rueff F et al (2011) Management of occupational hymenoptera allergy, Curr Opin Allergy Clin Immunol, 11(2): 69-74. Rueff F et al (2009) Stinging hymenoptera and mastocytosis, Curr Opin Allerg Clin Immunol, 9: 338-342.

Therapeutic Strategies in Dermatology

Flushing: Treatment

…gressive, or new onset flushing, one may perform a diagnostic work-up. Urinary 5-HIAA is a good screen for pheochromocytoma. Mastocytosis can be diagnosed with serum tryptase and urine histamine levels. Other vasoactive substances are less common…

Therapeutic Strategies in Dermatology

Flushing: Key Points

…ic hyperactivity; it can be associated with various endocrine-metabolic disorders (e.g., carcinoid tumors, pheochromocytoma, mastocytosis, hormonal insufficiency states, brain tumors) or with the use of certain drugs; and finally, it can occur as a…