Search Results for: mesenchymal cells

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Histologic Diagnosis of Inflammatory Skin Diseases

Cells That Mediate Inflammation (Inflammatory Cells)

…be derived from mesenchyme and to differentiate toward other mesenchymal cells such as those that make bone, cartilage, and muscle. Dermal fibrocytes are engaged in synthesis, degradation, and remodeling of connective tissue in skin. Recently, howev…

Dermatology Practical & Conceptual

Epidermal multinucleated giant cells are not always a histopathologic clue to a herpes virus infection: multinucleated epithelial giant cells in the epidermis of lesional skin biopsies from patients with acantholytic dermatoses can histologically mimic a herpes virus infection

Abstract Background: Multinucleated giant cells in the epidermis can either be epithelial or histiocytic. Epithelial multinucleated giant cells are most often associated with herpes virus infections. Purpose: To review the histologic differential di…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Benign and Malignant Cells?

“Tumor cells, benign or malignant, growing in vitro usually do not show any structural features that are pathognomonic of neoplasia.” Diamandopoulos GT. Neoplasia. In: Kissane JM, ed. Anderson’s Pathology. 8th ed. St. Louis, MO: C…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Nevus Cells, Nevocytes, and Nevomelanocytes?

…“A nevus (mole) is a benign neoplasm of pigment-forming cells, the nevus cell.” Lookingbill DP, Marks JG Jr. Principles of clinical diagnosis. In: Moschella SL, Hurley HJ, eds. Dermatology. 3rd ed. Philadelphia, PA: WB Saunders Co., 1992:…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Invasion by Neoplastic Cells?

….e., cancer, exhibits the properties of: 1. invasion when its cells infiltrate the surrounding normal tissue; and 2. metastasis, the capacity of cancer cells to spread and grow at sites distant from the origin of the neoplasm.” Harnden DG, McGe…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Trichodiscoma Related to the Hair Disk and Merkel-Cell Neoplasm to Merkel Cells?

…ion and immunohistochemistry. The tumor supposedly originates from Merkel cells.” Braun-Falco O, Plewig G, Wolff HH, et al. Mesenchymal tumors. In: Dermatology. Berlin, Germany: Springer-Verlag, 1991:1066. Search Derm101.com for trichodiscoma….

Histologic Diagnosis of Inflammatory Skin Diseases

Langerhans’ Cells

Langerhans’ cells, named for Paul Langerhans who, while a medical student in Berlin in 1868, was the first to describe them, are dendritic cells that reside just above the middle of the spinous zone of the epidermis. They make their appearance…

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