Search Results for: metastatic melanoma

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A Clinical Atlas of 101 Common Skin Diseases

Melanoma

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A malignant neoplasm of melanocytes that, in the skin, begins as a macule and may become a patch or a papule.

A Clinical Atlas of 101 Common Skin Diseases

Melanoma

…a macule and may become a patch or a papule. A flat lesion of melanoma tends to be asymmetrical, poorly circumscribed with a scalloped, jagged, or notched border, and variegate, mostly shades of brown. A patch may become a plaque or upon it may devel…

Therapeutic Strategies in Dermatology

Melanoma

…a macule and may become a patch or a papule. A flat lesion of melanoma tends to be asymmetrical, poorly circumscribed with a scalloped, jagged, or notched border, and variegate, mostly shades of brown. A patch may become a plaque or upon it may devel…

Therapeutic Strategies in Dermatology

Non-Melanoma Skin Cancers (NMSC): Basal Cell Carcinoma (BCC) and Squamous Cell Carcinoma (SCC): Non-Melanoma Skin Cancers (NMSC): Basal Cell Carcinoma (BCC) and Squamous Cell Carcinoma (SCC) – Initial Evaluation–Bowen’s Disease (Squamous Cell Carcinoma in Situ) – genprac

Initial Evaluation: Bowen’s Disease (Squamous Cell Carcinoma in Situ) The eponym Bowen’’s disease is used to describe squamous cell carcinoma in situ on any cutaneous surface except the glans penis. It bears several clinical features: Un…

Therapeutic Strategies in Dermatology

Melanoma: Key Points

…ation with regional experts is recommended. New therapies for metastatic melanoma that are immunomodulatory or target melanoma signaling pathways (anti-CTLA4, anti-PD1, BRAF inhibitors) have significantly changed the management of metastatic melanoma

Therapeutic Strategies in Dermatology

Melanoma: Treatment

…ecommended excision margins: European (Leiter U, et al. 2010) Melanoma in situ 0.5 cm 0.5 cm Breslow < 1 mm thickness 1 cm Breslow 1-2 mm 1-2 cm Breslow < 2 mm thickness 1 cm Breslow > 2 mm thickness 2 cm (at least) 2 cm Melanoma in situ sho…

Therapeutic Strategies in Dermatology

Melanoma: References

…ov 2014. Web. http: www.cancer.gov/cancertopics/pdq/treatment/melanoma/HealthProfessional Robert C, Thomas L, Bondarenko I, et al (2011) Ipilimumab plus dacarbazine for previously untreated metastatic melanoma, N Engl J Med 364 (26): 2517-26. Robert…

Therapeutic Strategies in Dermatology

Melanoma: Clinical Cases

…ain, chest, abdominal, and pelvic CT scans reveal evidence of metastatic disease in the lung and liver. Blood work is normal Genetic testing is done, which reveals a BRAF V600E mutation. He is referred to local melanoma oncologist and started on dual…

Therapeutic Strategies in Dermatology

Melanoma: Initial Evaluation

…regression) or more darkly pigmented raised areas (where the melanoma is arising). Malignant melanoma, metastatic Differential Diagnosis Melanocytic nevi Basal cell carcinoma, especially pigmented variants of basal cell carcinoma. Amelanotic (non-pi…

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