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Therapeutic Strategies in Dermatology

Lupus: Key Points

Key Points Lupus is a disease that presents across a broad spectrum of cutaneous and systemic manifestations. It may be cutaneous-only or systemic with cutaneous manifestations; some patients with systemic lupus do not have cutaneous involvement. D…

A Clinical Atlas of 101 Common Skin Diseases

Lupus Erythematosus

An inflammatory process that expresses itself in the skin in protean ways that are variations on a basic pathologic theme, and includes evanescent patches on the face (“butterfly blush”), scaly papules and plaques that resolve with atrop…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…cus of histiocytes in palisaded array around a zone made up of mucin and degeneration of collagen = Granuloma annulare Mucin in granuloma annulare usually is seen easily in sections stained by hematoxylin and eosin as blue-gray granular material, bu…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…Pallor throughout the reticular dermis is a result of abundant mucin there. Deposits of mucin like these may be seen in dermatomyositis, but the density of the infiltrate of lymphocytes militates against that diagnosis. 10.63.9A: Perivascular d…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Myxoma?

…1990:1020. “Lastly, neoplastic-hamartomatous cutaneous mucinosis include mucinous nevus, a benign hamartoma, and myxoma, which is a benign tumor to be differentiated from reactive cutaneous focal mucinosis.” Rongioletti F, Rebora A. Cu…

Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

In this section, algorithms used to reach specific diagnosis are predicated on “nonspecific” findings recognized best at higher magnification. Other changes requisite for specific diagnoses, i.e., denominators that are essential, then are added to a particular “nonspecific” finding, beginning with those attributes discernable at moderately high magnification and processing to those visualizable at progressively lower […]

Histologic Diagnosis of Inflammatory Skin Diseases

Lupus erythematosus

…f papules and plaques is smooth and devoid of scale. So-called mucinosis lupus erythematosus can be conceived of as a caricature of lupus tumidus, the amount of mucin in the reticular dermis being so great that plaques with a papillated surface come…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…ifolliculosis” + 11.14.9B: Epithelial (infundibular) mucinosis in company with an infiltrate of small lymphocytes and eosinophils = Mycosis fungoides, alopecia mucinosa expression ┬áThe infiltrate is present not only in the dermis, but also…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Lymphocytic Infiltration of Jessner?

…d of edema or from those of tumid lupus erythematosus in which mucin is scant. In our experience, however, lesions thought by clinicians to be examples of lymphocytic infiltration of Jessner and Kanof often house copious amounts of mucin in the retic…

Histologic Diagnosis of Inflammatory Skin Diseases

Nephrogenic fibrosing dermopathy

Nephrogenic fibrosing dermopathy Presentation stereotypical Age and Sex Adults of either sex, rarely children Distribution of lesions Extremities, particularly legs and feet, less often trunk and buttocks Arrangement of lesions Confluence to plaques…

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