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Therapeutic Strategies in Dermatology

Spider Bites: Key Points

Key Points Spiders are 8-legged (arthropod) members of the order Araneae. Spider bites result from a self-defense reaction when a spider feels threatened and typically arise due to inadvertent meeting with a spider (i.e., accidental). There are sev…

Therapeutic Strategies in Dermatology

Psoriasis: Principles of Psoriasis Management

Principles of Psoriasis Management Topical therapy is usually appropriate for treatment of patients with less than 10% body surface area (see table below). Systemic therapies (see table below) are indicated when one or more of the following are pre…

Therapeutic Strategies in Dermatology

Spider Bites: Treatment

…milar manner to a brown recluse bite, characterized by central necrosis and a rapidly expanding ulcer. Primary pyoderma, especially with methicillin-resistant S. aureus may present with pain, swelling, and necrosis. This diagnosis is much more likely…

Histologic Diagnosis of Inflammatory Skin Diseases

Subcutaneous fat necrosis of the newborn

…debilitated newborns. Findings histopathologic Early Granular necrosis of adipocytes in lobules in the subcutaneous fat Sparse infiltrate of neutrophils, especially in zones of fat necrosis; septa sometimes also involved by the infiltrate of inflamm…

Histologic Diagnosis of Inflammatory Skin Diseases

Traumatic fat necrosis

Traumatic fat necrosis Synonyms Traumatic fatty necrosis Traumatic panniculitis Presentation stereotypical Age and sex Any age, especially females Distribution of lesions Localized to sites of trauma Individual lesions Plaques and nodules Course If…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Apoptosis?

“… this distinctive type of necrosis (apoptosis)…has previously been called shrinkage necrosis on morphological grounds.” Kerr JFR. Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide ranging implicatio…

Histologic Diagnosis of Inflammatory Skin Diseases

Applicable Terms

…#8220;flame figures.” The term degeneration, rather than necrosis, is proper for these changes because necrosis is possible only for cells that are viable; fibrocytes, i.e., viable cells, can undergo necrosis, but collagen, i.e., fibrous tissue…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Perivascular Dermatitis

…icular alteration and one that is associated, invariably, with necrosis of keratocytes in the zone of epidermis affected (Fig. 5.85 A&B). It should be noted, however, that severe ballooning of spinous cells may lead to necrosis of individual kera…

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