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Therapeutic Strategies in Dermatology

Spider Bites: Key Points

…troduced by their bites; these can result in inflammation and necrosis of the skin. Some spider bites can result in systemic symptoms. Fatal spider bites are extremely rare; in the 20th century, there were fewer than 100 confirmed deaths due to spide…

Therapeutic Strategies in Dermatology

Psoriasis: Principles of Psoriasis Management

…immunologic mediators involved in psoriasis, including tumor necrosis factor alpha (TNF-A), may offer effective treatments with fewer side effects than the more broadly acting immunosuppressive agents. These agents are relatively new but have proven…

Therapeutic Strategies in Dermatology

Spider Bites: Treatment

…ilar manner to a brown recluse bite, characterized by central necrosis and a rapidly expanding ulcer. Primary pyoderma, especially with methicillin-resistant S. aureus may present with pain, swelling, and necrosis. This diagnosis is much more likely…

Histologic Diagnosis of Inflammatory Skin Diseases

Subcutaneous fat necrosis of the newborn

Subcutaneous fat necrosis of the newborn Synonyms Adiponecrosis subcutanea neonatorum Presentation stereotypical Age and sex Healthy full-term newborns Distribution of lesions Buttocks, thighs, shoulders, back, or arms Individual lesions Dusky-red n…

Histologic Diagnosis of Inflammatory Skin Diseases

Traumatic fat necrosis

Traumatic fat necrosis Synonyms Traumatic fatty necrosis Traumatic panniculitis Presentation stereotypical Age and sex Any age, especially females Distribution of lesions Localized to sites of trauma Individual lesions Plaques and nodules Course If…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Apoptosis?

“… this distinctive type of necrosis (apoptosis)…has previously been called shrinkage necrosis on morphological grounds.” Kerr JFR. Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide ranging implicatio…

Histologic Diagnosis of Inflammatory Skin Diseases

Applicable Terms

…ed an abscess; when the neutrophils are joined by products of necrosis and degeneration, it is termed suppuration. The abscess most often recognizable clinically results from rupture of an infundibular cyst and the circumstance in which that develops…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Perivascular Dermatitis

…cular alteration and one that is associated, invariably, with necrosis of keratocytes in the zone of epidermis affected (Fig. 5.85 A&B). It should be noted, however, that severe ballooning of spinous cells may lead to necrosis of individual kerat…

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