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Therapeutic Strategies in Dermatology

Hidradenitis Suppurativa: Key Points

Key Points Hidradenitis suppurativa (HS) is a chronic inflammatory process affecting skin bearing apocrine glands; the groin, axillae, and inframammary areas are typically involved. The classic lesions of HS include cysts, nodules, sinus tracts, an…

Therapeutic Strategies in Dermatology

Hidradenitis Suppurativa: References

…Alhusayen R, Shear NJ (2012). Pharmacologic intervention for hidradenitis suppurativa: what does the evidence say? Amer J Clin Derm, 13: 283-291. Alikhan A, Lynch PJ, Eisen DB (2009). Hidradenitis suppurativa: a comprehensive review (CME), JAAD, 60:…

Therapeutic Strategies in Dermatology

Sweet’s Syndrome (Acute Febrile Neutrophil Dermatosis): Key Points

…ternative immunosuppression with steroid-sparing agents. Anti-neutrophilic agents often are effective in the management of Sweet’s syndrome. Introduction Indurated, often painful, erythematous nodules are the characteristic skin lesion that marks Sw…

Therapeutic Strategies in Dermatology

Hidradenitis Suppurativa: Treatment

…rst-line therapy: The first-line therapy for mild to moderate hidradenitis suppurativa is topical or systemic antibiotics. For very severe disease, systemic immunosuppression, specifically with anti-TNF-alpha inhibitors, may be first-line. First step…

Therapeutic Strategies in Dermatology

Alopecia: Key Points

…r a specific histopathologic pattern (the distinction between neutrophilic versus lymphocytic scarring alopecia informs treatment directed at a particular immune cell-i.e., dapsone for neutrophils or mycophenolate mofetil for lymphocytes). If a prima…

Therapeutic Strategies in Dermatology

Sweet’s Syndrome (Acute Febrile Neutrophil Dermatosis): References

References Brinster NK et al (2012) Nonbullous neutrophilic lupus erythematosus: a newly recognized variant of cutaneous lupus erythematosus, JAAD, 66(1):92-97. Dabade TS, Davis MD (2011) Diagnosis and treatment of the neutrophilic dermatoses (pyode…

Therapeutic Strategies in Dermatology

Pyoderma Gangrenosum: Key Points

Key Points Pyoderma gangrenosum is a type of ulcerating neutrophilic dermatosis. The classic morphology of pyoderma gangrenosum is an ulcer with a violaceous rim and undermined border. PG lesions may develop very rapidly (in days) and may be trigg…

Therapeutic Strategies in Dermatology

Hidradenitis Suppurativa: Clinical Cases

…tracts with moderate erythema in bilateral axillae Diagnosis: hidradenitis suppurativa No skin biopsy is required Treatment options discussed; patient opts for systemic antibiotics. Rifampin 300 mg bid and clindamycin 300 mg b.i.d. is prescribed Intr…

Therapeutic Strategies in Dermatology

Granuloma Annulare: Key Points

…active granulomatous processes in the skin (such as palisaded neutrophilic and granulomatous dermatitis or interstitial granulomatous dermatitis). Others have suggested that GA represents a delayed hypersensitivity response to an unidentified host an…

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