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Therapeutic Strategies in Dermatology

Alopecia: Key Points

…atment directed at a particular immune cell-i.e., dapsone for neutrophils or mycophenolate mofetil for lymphocytes). If a primary medical illness is suspected, or to rule out common causes of medically related hair loss or exacerbation of hair loss,…

Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

…lar and interstitial infiltrate of lymphocytes, plasma cells, neutrophils, and eosinophils = Tick bite reaction + Keratocytes with steel-gray nuclei and “margination” of chromatin or even with no epidermal changes, but edema of the papi…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

….1A: Perivascular and interstitial dermatitis + 10.58.1B: Neutrophils and copious quantities of nuclear “dust” of neutrophils in association with many extravasated erythrocytes = Leukocytoclastic vasculitis, early Even when fibrin is…

Histologic Diagnosis of Inflammatory Skin Diseases

Cells That Mediate Inflammation (Inflammatory Cells)

Neutrophils, eosinophils, lymphocytes, plasma cells, and histiocytes are called inflammatory cells because they enter tissue during the process of inflammation. A more exact designation for them is “cells of an inflammatory process”; the…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

….1A: Perivascular and interstitial dermatitis + 10.19.1B: Neutrophils and nuclear “dust” at the tip of edematous dermal papillae, obscuration of the junction by inflammatory cells, and hints of subepidermal fibrin = Linear IgA dermato…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Perivascular Dermatitis

…A&B). In some perivascular and interstitial dermatitides, neutrophils predominate in the interstitium. That is the case for some examples of urtica (Fig. 5.30 A&B) (in other examples, eosinophils are preponderant in the interstitium), which i…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Vesicular Dermatitis

…its course, is a spongiotic dermatitis, lymphocytes preceding neutrophils into the epidermis of it (Fig. 5.261 A&B). A caricature of the spongiotic process in psoriasis is witnessed in a spongiotic psoriasiform manifestation on volar skin that, a…

Histologic Diagnosis of Inflammatory Skin Diseases

Applicable Terms

…tion of pus and histopathologically a localized collection of neutrophils. An abscess may form in the epidermis, both surface and infundibular, eccrine ducts, dermis, and subcutaneous fat, or in parts of any other organ (Fig. 3.1), and it may come in…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…ular dermatitis, psoriasiform + 10.90.1B: Lymphocytes and neutrophils around venules, dilated tortuous capillaries in edematous dermal papillae, spongioform pustules, and tiers of neutrophil-containing mounds of parakeratosis = Psoriasis, early  …

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