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Therapeutic Strategies in Dermatology

Alopecia: Key Points

Key Points Alopecia, or hair loss, has a broad spectrum of causes. In order to appropriately treat alopecia, the type of hair loss or pathophysiology must be clearly identified. The evaluation for hair loss requires a very thorough history and phys…

Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

In this section, algorithms used to reach specific diagnosis are predicated on “nonspecific” findings recognized best at higher magnification. Other changes requisite for specific diagnoses, i.e., denominators that are essential, then are added to a particular “nonspecific” finding, beginning with those attributes discernable at moderately high magnification and processing to those visualizable at progressively lower […]

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…8.1A: Perivascular and interstitial dermatitis + 10.58.1B: Neutrophils and copious quantities of nuclear “dust” of neutrophils in association with many extravasated erythrocytes = Leukocytoclastic vasculitis, early Even when fibrin is…

Histologic Diagnosis of Inflammatory Skin Diseases

Cells That Mediate Inflammation (Inflammatory Cells)

Neutrophils, eosinophils, lymphocytes, plasma cells, and histiocytes are called inflammatory cells because they enter tissue during the process of inflammation. A more exact designation for them is “cells of an inflammatory process”; the…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…etiformis. 10.19.2A: Vesicular dermatitis, subepidermal, neutrophils predominant + 10.19.2B: Neutrophils in edematous dermal papillae and in subepidermal spaces = Dermatitis herpetiformis The blister in this lesion is incipient. Changes ide…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Perivascular Dermatitis

…. Diagnosis with specificity. An infiltrate of lymphocytes and neutrophils around venules, and neutrophils scattered in the interstitium is typical of urtica. Figure 5.31 A&B. Diagnosis with specificity. Neutrophils distributed particularly al…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Vesicular Dermatitis

…apillae and mounds of parakeratosis that at their summit house neutrophils, but by spongiosis mediated by lymphocytes. As a rule, lymphocytes precede neutrophils in the epidermis of psoriasis. Figure 5.262 A&B. Distinctive findings in the corn…

Histologic Diagnosis of Inflammatory Skin Diseases

Applicable Terms

…he skin most abscesses are not a consequence of infection. The neutrophils in an abscess release enzymes, including proteases that then cause destruction of tissue, the constellation of neutrophils, cellular debris, and liquefied tissue that results…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…0.90.2A: Perivascular dermatitis, psoriasiform + 10.90.2B: Neutrophils in elongated mounds of parakeratosis in tiers throughout the cornified layer = Psoriasis, early ┬áSigns of an eruptive phase are edema in the papillary dermis and neutrophils i…

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