Therapeutic Strategies in Dermatology

Erythema Multiforme: Key Points

Key Points Erythema multiforme (EM) is a clinical syndrome marked by either target lesions and/or mucosal erosions. It may be idiopathic or seen in association with infections or medications. EM has been reported in association with herpes simplex…

Histologic Diagnosis of Inflammatory Skin Diseases

Farmyard pox

…G, Tulman ER, Afonso CL, et al. Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus. J Virol. 2004 Jan;78(1):168-77. Haig DM, Mercer AA. Ovine diseases. Orf. Vet Res. 1998 May-Aug;29(3-4):311-26. Hansen GA. Nor Tidsskr Vet 18…

Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

In this section, algorithms used to reach specific diagnosis are predicated on “nonspecific” findings recognized best at higher magnification. Other changes requisite for specific diagnoses, i.e., denominators that are essential, then ar…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Vesicular Dermatitis

See Fig. 5.239 A-C. Figure 5.239 A-C. Patterns of vesiculation: intraepidermal, subepidermal, and intra- and subepidermal. “Blister” and “vesiculobullous” are terms generic for lesions of the skin that usually are elevated…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.36.1A: Diffuse dermatitis, mixed-cell, and pseudocarcinomatous proliferation of keratocytes + 10.36.1B: Amphophilic ovoid bodies in the cytoplasm of infundibular keratocytes = Milker’s nodule Changes identical with these a…

Histologic Diagnosis of Inflammatory Skin Diseases

Introduction

Capability for accurate diagnosis of inflammatory skin diseases, clinically and histopathologically, requires familiarity thoroughly with embryologic, histologic, and anatomic aspects of the skin. Although examples of this precept are legion, only a…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Toxic Erythema?

“Toxic erythema: Red or pinkish color of the skin, if localized, probably due to external cause; if generalized, frequently of internal origin such as derangement of the gastrointestinal tract; ingestion of drugs or antitoxin.” Knowles…