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Histologic Diagnosis of Inflammatory Skin Diseases

Cells That Mediate Inflammation (Inflammatory Cells)

Neutrophils, eosinophils, lymphocytes, plasma cells, and histiocytes are called inflammatory cells because they enter tissue during the process of inflammation. A more exact designation for them is “cells of an inflammatory process”; the…

Dermatology Practical & Conceptual

Epidermal multinucleated giant cells are not always a histopathologic clue to a herpes virus infection: multinucleated epithelial giant cells in the epidermis of lesional skin biopsies from patients with acantholytic dermatoses can histologically mimic a herpes virus infection

Abstract Background: Multinucleated giant cells in the epidermis can either be epithelial or histiocytic. Epithelial multinucleated giant cells are most often associated with herpes virus infections. Purpose: To review the histologic differential di…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Benign and Malignant Cells?

…. Rather than trying to kll the highly dysplastic or malignant cells directly, a benign cell booster increases the fitness of the more benign cells, which may be either normal or benign clones, so that they may outcompete more advanced or malignant c…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Nevus Cells, Nevocytes, and Nevomelanocytes?

…unders Co., 1992:210. “It is well documented that nevus cells can be found within the fibrous capsule and trabeculae of lymph nodes; however, it is less well known that nevus cells can also b found in the lymph node parenchyma.” Biddle…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Invasion by Neoplastic Cells?

…i.e., cancer, exhibits the properties of: 1. invasion when its cells infiltrate the surrounding normal tissue; and 2. metastasis, the capacity of cancer cells to spread and grow at sites distant from the origin of the neoplasm.” Harnden DG, Mc…

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