Histologic Diagnosis of Inflammatory Skin Diseases

Pellagra

Pellagra Synonyms Niacin deficiency Presentation stereotypical Age and sex Any age and either sex; more common in developing countries in which malnutrition is prevalent, but may be seen in industrialized countries where factors for malnutrition, e….

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…a front across the entire upper part of the viable epidermis = Pellagra ¬†On grounds histopathologic alone, all that can be said of the findings pictured here is that they are those of a deficiency disease, one of which is pellagra, the others being a…

Histologic Diagnosis of Inflammatory Skin Diseases

Bibliography

…go Pelagram (sic). Milan: 1771. Hegyi J, Schwartz RA, Hegyi V. Pellagra: dermatitis, dementia, and diarrhea. Int J Dermatol 2004;43(1):1-5. Hendricks WM. Pellagra and pellagra-like dermatoses: Etiology, differential diagnosis, dermatopathology, and t…

Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

In this section, algorithms used to reach specific diagnosis are predicated on “nonspecific” findings recognized best at higher magnification. Other changes requisite for specific diagnoses, i.e., denominators that are essential, then ar…

Histologic Diagnosis of Inflammatory Skin Diseases

Necrolytic migratory erythema

Necrolytic migratory erythema Synonyms Erythema necroticans migrans Glucagonoma syndrome Pseudoglucagonoma syndrome Presentation stereotypical Age and sex Middle-aged or elderly persons of both sexes with increased levels of serum glucagon Distrib…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Perivascular Dermatitis

See Figs. 5.16 A&B, 5.17 A&B, 5.18 A&B, 5.19 A&B, 5.20 A&B, 5.21 A&B, and 5.22 A&B Figure 5.16 A. Perivascular dermatitis, perivascular only, superficial. B. Perivascular dermatitis, perivascular only, superficial and…

Histologic Diagnosis of Inflammatory Skin Diseases

Acrodermatitis enteropathica

Acrodermatitis enteropathica Synonyms Zinc deficiency Presentation stereotypical Age and sex Infants of both sexes who suffer from an inherited deficiency of zinc; may occur in adults; characterized in infants by a triad of acral dermatitis, alopeci…

Histologic Diagnosis of Inflammatory Skin Diseases

Advantages of the Algorithmic Method

By utilizing an algorithmic method based mostly on analysis of patterns formed by inflammatory cells, of alterations in epidermal and adnexal epithelium, and of the character of the inflammatory cells themselves, order can be brought to a subject ab…

Histologic Diagnosis of Inflammatory Skin Diseases

Syphilis

Syphilis Synonyms Lues Presentation stereotypical Age and sex Young, sexually active adults of both sexes Distribution of lesions Localized (usually to genitalia) as a chancre of primary syphilis, widespread lesions in secondary syphilis, and locali…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Pustular Dermatitis

See Fig. 5.307 A&B. Figure 5.307 Pustular dermatitis. A. Infundibular. B. Surface epidermal. Although most pustules in skin are housed in infundibular epidermis (Fig. 5.308 A&B), many are lodged in surface epidermis (Fig. 5.309 A&B)….