Search Results for: pellagra

Histologic Diagnosis of Inflammatory Skin Diseases

Pellagra

…ynthesis of serotonin, thereby shunting it from synthesis of niacin. Pyridoxine (vitamin B6) deficiency is associated with a pellagra-like eruption, sometimes indistinguishable from that of pellagra because pyridoxine is a coenzyme in tryptophan…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…hosis + 10.18.2B: Pallor of somewhat ballooned keratocytes in a front across the entire upper part of the viable epidermis = Pellagra On grounds histopathologic alone, all that can be said of the findings pictured here is that they are those of a…

Histologic Diagnosis of Inflammatory Skin Diseases

Bibliography

…1. Hegyi J, Schwartz RA, Hegyi V. Pellagra: dermatitis, dementia, and diarrhea. Int J Dermatol 2004;43(1):1-5. Hendricks WM. Pellagra and pellagra-like dermatoses: Etiology, differential diagnosis, dermatopathology, and treatment. Semin Dermatol…

Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

…pidermal blister = Re-epithelialization of epidermis + Scale-crusts, often containing neutrophils, and variable acanthosis = Pellagra/Necrolytic migratory erythema/Acrodermatitis enteropathica, etc. + Parakeratosis containing neutrophils, mitotic…

Histologic Diagnosis of Inflammatory Skin Diseases

Necrolytic migratory erythema

…ed of parakeratosis, serum, and, at times, neutrophils. Differential diagnosis histopathologic Acrodermatitis enteropathica, pellagra, Hartnup’s disease, kwashiorkor, and maple syrup disease have identical findings histopathologic. Laboratory…

Histologic Diagnosis of Inflammatory Skin Diseases

Acrodermatitis enteropathica

…or of cells in the upper part of the spinous layer is a clue to acrodermatitis enteropathica, necrolytic migratory erythema, pellagra, Hartnup’s disease, kwashiorkor, and maple syrup disease, as well as to evolving lesions of psoriasis,…

Histologic Diagnosis of Inflammatory Skin Diseases

Advantages of the Algorithmic Method

…rogressive systemic sclerosis (acrosclerosis, diffuse systemic sclerosis, toxic oil syndrome) Deficiency diseases (including pellagra, acrodermatitis enteropathica, necrolytic migratory erythema, Hartnup’s disease, kwashiorkor, and maple syrup…

Histologic Diagnosis of Inflammatory Skin Diseases

Syphilis

…riking pallor of cells in the upper part of the spinous zone and the granular layer is a clue to deficiency diseases such as pellagra, acrodermatitis enteropathica, and necrolytic migratory erythema, and to evolving lesions of psoriasis,…