Histologic Diagnosis of Inflammatory Skin Diseases

Sclerema neonatorum

Sclerema neonatorum Presentation stereotypical Age and sex Neonates of both sexes Distribution of lesions Beginning on buttocks, extending to thighs and calves, and later reaching to the trunk sometimes Individual lesions Plaques and nodules Course…

A Clinical Atlas of 101 Common Skin Diseases

Pemphigus Vulgaris

A blistering disease of skin and mucous membranes that presents itself in the skin first as flaccid bullae that soon become eroded, and in mucous membranes as erosions, hemorrhagic crusts, or both. If widespread and untreated, the disease can be fat…

A Clinical Atlas of 101 Common Skin Diseases

Pemphigus Foliaceus

A blistering inflammatory disease in which acantholysis occurs in the upper part of the spinous zone or granular zone of the epidermis, the result of the process being flaccid blisters that give way to erosions and crusts accompanied by erythema. Wh…

Histologic Diagnosis of Inflammatory Skin Diseases

Poststeroid panniculitis

…one another histopathologically, but are different clinically. Sclerema neonatorum displays needle-shaped clefts in adipocytes, not in histiocytes in the subcutaneous fat of children, as is the situation in subcutaneous fat necrosis of the newborn an…

Histologic Diagnosis of Inflammatory Skin Diseases

Subcutaneous fat necrosis of the newborn

…ed nodules Course Self-limited Differential diagnosis clinical Sclerema neonatorum is manifested by diffuse hardening of the skin of debilitated newborns. Findings histopathologic Early Granular necrosis of adipocytes in lobules in the subcutaneous…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…n and its lookalike, poststeroid panniculitis, on one hand and sclerema neonatorum on the other. The crystals shown are present in macrophages, whereas in sclerema neonatorum they are present in adipocytes almost entirely. 10.101.2A: Panniculit…

Histologic Diagnosis of Inflammatory Skin Diseases

Cold panniculitis

…urple nodules on the cheeks, back, buttocks, arms, and thighs. Sclerema neonatorum affects infants debilitated by a severe disease underlying, e.g., catastrophic dehydration secondary to acute gastroenteritis; indurated plaques that develop rapidly u…

Histologic Diagnosis of Inflammatory Skin Diseases

Toxic erythema of the newborn

Toxic erythema of the newborn Synonyms Erythema neonatorum Erythema toxicum Erythema neonatorum allergicum Presentation stereotypical Age and sex Neonates during the first few days of life Distribution of lesions Widespread Arrangement of lesions Sc…

Differential Diagnosis in Dermatopathology

Discussions

…d lichen myxedematosis, is an expression of a paraproteinemia; sclerema neonatorum is a consequence of enzymatic abnormalities in adipocytes that result in an increased ratio of saturated to unsaturated fatty acids and deposits of triglyceride crysta…