Search Results for: scleromyxedema

Histologic Diagnosis of Inflammatory Skin Diseases

Scleromyxedema

…lls. Mucin is hyaluronidase sensitive and Alcian blue positive at pH 2.5. Cause and mechanism Not known. The relationship of scleromyxedema to paraproteinemia also is not understood. Comment Scleromyxedema does not qualify as an inflammatory disease…

Histologic Diagnosis of Inflammatory Skin Diseases

Nephrogenic fibrosing dermopathy

…ining immunohistochemically may be helpful for diagnosis. In our opinion, nephrogenic fibrosing dermopathy is not related to scleromyxedema, as Cowper and colleagues had thought initially, or to scleroderma, as some authors have averred, despite…

Differential Diagnosis in Dermatopathology

Discussions

…ions stained by hematoxylin and eosin, mucin appears as basophilic granular and stringy material. At scanning magnification, scleromyxedema seems to be a kind of fibroplasia, whereas pretibial myxedema clearly is a mucinosis. Strictly speaking,…

Histologic Diagnosis of Inflammatory Skin Diseases

Errors and Reasons

…ut, in practice, hardly ever is that encountered, even in authentic vasculitis. Error: Nephrogenic fibrosing dermopathy is a scleromyxedema-like condition that develops in patients on renal dialysis. Reason: It is a scleroderma-like condition in…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…2A: No infiltrate of inflammatory cells + 11.18.2B: Fibrocytes and mast cells amidst mucin in the upper part of the dermis = Scleromyxedema At scanning magnification, a papule is seen to consist largely of mucin, in contrast to the changes in the…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…e and usually on renal dialysis, is yet to be elucidated. It seems, however, to be unique, surely different from morphea and scleromyxedema. 10.69.2A: Fibrosing dermatitis, panniculitis, septal, and fasciitis + 10.69.2B: Fibrocytes scattered among…

Rongioletti F, Smoller BR (eds). Clinical and Pathological Aspects of Skin Diseases in Endocrine, Metabolic, Nutritional and Deposition Disease. New York: Springer; 2010

Rongioletti F, Smoller BR (eds). Clinical and Pathological Aspects of Skin Diseases in Endocrine, Metabolic, Nutritional and Deposition Disease. New York: Springer; 2010

…iderosis around eccrine glands may be specific for idiopathic hemochromatosis, and the linear array of papules is a clue for scleromyxedema as opposed to scleredema or scleroderma. A treatment pearl is using the hyperpigmentation of Addison disease…