Histologic Diagnosis of Inflammatory Skin Diseases

Scleromyxedema

Scleromyxedema Synonyms Papular mucinosis Lichen myxedematosus Presentation stereotypical Age and sex Adults of either sex Distribution of lesions Widespread Individual lesions Papules that produce diffuse thickening of the skin Course Protracted Va…

Histologic Diagnosis of Inflammatory Skin Diseases

Nephrogenic fibrosing dermopathy

Nephrogenic fibrosing dermopathy Presentation stereotypical Age and Sex Adults of either sex, rarely children Distribution of lesions Extremities, particularly legs and feet, less often trunk and buttocks Arrangement of lesions Confluence to plaques…

Differential Diagnosis in Dermatopathology

Discussions

…osclerotic form of scleroderma. Other features associated with scleromyxedema are light-chain immunoglobulinopathy that involves IgG and episodically multiple myeloma. The mucin in both pretibial myxedema and scleromyxedema is hyaluronic acid because…

Histologic Diagnosis of Inflammatory Skin Diseases

Errors and Reasons

Error: Abortive is an accurate modifier of particular pathologic processes, e.g., abortive dermatofibroma, abortive morphea, and abortive T-cell lymphoma. Reason: The idea itself is abortive! For example, what is called “abortive T-cell lympho…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 11.18.1A: Perivascular and interstitial dermatosis + 11.18.1B: Large amount of mucin in company with scattered spindle- and stellate-shaped fibrocytes, as well as mast cells = Scleromyxedema, early ┬áThis is an early lesion because…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.69.1A: Fibrosing dermatitis and panniculitis, septa + 10.69.1B: Patchy infiltrates of fibrocytes in association with fibrillary bundles of collagen throughout much of the reticular dermis and in some septa of the subcutaneous fa…