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Therapeutic Strategies in Dermatology

Persistent Pigmented Purpuric Dermatitis: Overview

…ew This group of diseases includes Schamberg’s disease, purpura annularis telangiectodes (of Majocchi), lichenoid pigmented purpura (of Gougerot and Blum), eczematoid purpura of Doucas and Kapetanakis (disseminated pruriginous angiodermatitis),…

Therapeutic Strategies in Dermatology

Lichen Planus: Initial Evaluation

…fferential diagnosis Leukocytoclastic vasculitis, or palpable purpura, presents as violaceous-to-purpuric papules occasionally with a central pustule, vesiculation, or necrosis often in dependent areas, such as the legs, hips, and buttocks….

A Clinical Atlas of 101 Common Skin Diseases

Persistent Pigmented Purpuric Dermatitis

…ules and subtle papules (Schamberg’s disease), lichenoid papules (lichenoid purpura of Gougerot-Blum), and scaly papules (eczematid-like purpura of Doucas and Kapetanakis), all of which seem to be variants of the same basic pathologic process….

A Clinical Atlas of 101 Common Skin Diseases

Allergic (Leukocytoclastic) Vasculitis

A systemic inflammatory process involving venules by deposits of fibrin within their wall in conjunction with neutrophils and nuclear “dust” of neutrophils in the dermis and, at times, the subcutaneous fat. The clinical manifestations ar…

Therapeutic Strategies in Dermatology

Pernio/Chilblains: Key Points

…lain lupus erythematosus. The presence of angulated, retiform purpura, or nonblanching sharply angled distal lesions, may prompt a consideration of a systemic thromboembolic disease, including cryoglobulinemia or anti-phospholipid antibody syndrome….

Therapeutic Strategies in Dermatology

Pernio/Chilblains: Treatment

…tems and targeted laboratory workup. The presence of retiform purpura or nonblanching purpuric lesions should prompt consideration for a thrombotic process such as cryoglobulinemia or anti-phospholipid antibody syndrome Chronic myelomonocytic leukemi…

Therapeutic Strategies in Dermatology

Leukocytoclastic Vasculitis: Key Points

…present in the setting of a syndrome such as Henoch-Sch√∂nlein purpura (HSP), typified by the triad of cutaneous LCV (IgA deposition), arthritis, and gastrointestinal involvement in which the skin lesions predominantly affect the lower extremities and…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Palpable Purpura?

…the prominent clinical features of leukocytoclastic angiitis. Purpura is almost always present in the cutaneous lesions and is frequently accompanied by evidence of increased vascular permeability. Therefore, purpura, when present, is almost always p…

A Clinical Atlas of 101 Common Skin Diseases

Septic Vasculitis

A small-vessel vasculitis characterized clinically by vesiculopustules on an erythematous base, purpuric macules and papules, and hemorrhagic bullae, and histopathologically by thrombi within venules, a consequence of sepsis….

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