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A Clinical Atlas of 101 Common Skin Diseases

Lymphomatoid Papulosis

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A distinctive type of CD 30 lymphoma characterized by the presence mostly of papules, some of them purpuric, that may ulcerate and heal with a scar, and by lesions that tend to come and go for years, eventually disappearing entirely or, on occasion, becoming nodular and even tumorous, which is an indication of likelihood of detectable lymphomatous involvement of some organs besides the skin.

Therapeutic Strategies in Dermatology

Melanoma: Treatment

…d be considered for more extensive baseline evaluation such as sentinel lymph node biopsy and/or searching for metastases (CT or MRI of the brain, chest, abdomen or pelvis, or PET CT). Ancillary therapy The decision to pursue regional sentinel lymph

Therapeutic Strategies in Dermatology

Melanoma: Key Points

…H, lactate dehydrogenase. *Micrometastases are diagnosed after sentinel lymph node biopsy.†Macrometastases are defined as clinically detectable nodal metastases confirmed pathologically. Table 2. Depth of melanoma invasion based on histopathologic le…

Therapeutic Strategies in Dermatology

Cutaneous T-Cell Lymphoma/ Mycosis Fungoides: Overview

…es or plaques < o r> 10% body surface area with palpable lymph nodes without pathologic involvement Stage IIB-tumors with or without palpable lymph nodes in the absence of pathologic involvement Stage III-erythroderma with or without palpable l…

Therapeutic Strategies in Dermatology

Melanoma: Clinical Cases

…s performed and does not identify any other suspicious lesions Biopsy: melanoma, 2.1 mm thickness Follow-up The patient undergoes wide local excision with 2 cm margins and elects to have sentinel lymph node mapping and dissection, which reveals 2 o…

Therapeutic Strategies in Dermatology

Kaposi’s Sarcoma: Overview

…mor regression in slightly over 50% of patients. For localized lymphatic and mucosal disease, radiation therapy in fractionated doses may help control lymph node disease and the associated lymphedema. Patients with mucosal disease may require signifi…

Therapeutic Strategies in Dermatology

Melanoma: References

…es, Clinics in Dermatology, 28:311-315. Morton DL et al (2006) Sentinel-node biopsy or nodal observation in melanoma, NEJM, 355:1307-1317. National Cancer Institute. Melanoma Treatment (PDQ). 7 Nov 2014. Web. http: www.cancer.gov/cancertopics/pdq/tre…

Therapeutic Strategies in Dermatology

Alopecia: Clinical Cases

…ther manifestations of hyperandrogenism or virilization A skin biopsy is offered to the patient, which she accepts; she is highly-motivated to confirm the diagnosis of androgenetic alopecia; a 4 mm punch biopsy of the affected area of alopecia is per…

Therapeutic Strategies in Dermatology

Extramammary Paget’s/Paget’s Disease: Overview

…ut between 25% and 50% have an associated carcinoma. A careful lymph node evaluation is essential. Immunoperoxidase markers on paraffin fixed tissue can be used to identify the source of the primary carcinoma, or confirm that the lesion arose in the…

Therapeutic Strategies in Dermatology

Pyoderma Gangrenosum: Clinical Cases

…ulocytes noted on peripheral smear, and widespread mediastinal lymphadenopathy is noted on chest X-ray The patient is referred to hematology/oncology for a bone marrow biopsy Ongoing wound care with clobetasol ointment under occlusion is recommended…

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