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A Clinical Atlas of 101 Common Skin Diseases

Lymphomatoid Papulosis

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A distinctive type of CD 30 lymphoma characterized by the presence mostly of papules, some of them purpuric, that may ulcerate and heal with a scar, and by lesions that tend to come and go for years, eventually disappearing entirely or, on occasion, becoming nodular and even tumorous, which is an indication of likelihood of detectable lymphomatous involvement of some organs besides the skin.

Therapeutic Strategies in Dermatology

Melanoma: Treatment

…ceration or mitotic index > 1/mm2) should be considered for sentinel lymph node biopsy (Balch CM, et al. AJCC 2009). Adjuvant treatment after surgery with interferon-alpha-2b has proven a disease-free survival benefit, and further clinical trials…

Therapeutic Strategies in Dermatology

Cutaneous T-Cell Lymphoma/ Mycosis Fungoides: Overview

…es or plaques < o r> 10% body surface area with palpable lymph nodes without pathologic involvement Stage IIB-tumors with or without palpable lymph nodes in the absence of pathologic involvement Stage III-erythroderma with or without palpable l…

Therapeutic Strategies in Dermatology

Melanoma: Principles of Management of Melanoma

…H, lactate dehydrogenase. *Micrometastases are diagnosed after sentinel lymph node biopsy. †Macrometastases are defined as clinically detectable nodal metastases confirmed pathologically. Table 2. Clark’s Level Level of invasion I Lesion i…

Therapeutic Strategies in Dermatology

Melanoma: Clinical Cases

…rgoes wide local excision with 2 cm margins and elects to have sentinel lymph node mapping and dissection, which reveals no affected lymph nodes Brain, chest, abdominal, and pelvic CT scans do not reveal evidence of metastatic disease Subsequent fol…

Therapeutic Strategies in Dermatology

Kaposi’s Sarcoma: Overview

…mor regression in slightly over 50% of patients. For localized lymphatic and mucosal disease, radiation therapy in fractionated doses may help control lymph node disease and the associated lymphedema. Patients with mucosal disease may require signifi…

Therapeutic Strategies in Dermatology

Melanoma: References

References National Cancer Institute: http://www.cancer.gov (2009) Melanoma Treatment (PDQ). Dummer R et al (2008) Cutaneous malignant melanoma: ESMO clinical recommendations for diagnosis, treatment and follow-up, Ann Oncol, 19:ii86-88. Garbe C et…

Therapeutic Strategies in Dermatology

Melanoma: Key Points

…he primary tumor? Which patients should have elective regional lymph node dissection? Is there an efficient adjuvant treatment to prevent relapses, which patients will benefit from it? Referral to regional centers or consultation with regional der…

Therapeutic Strategies in Dermatology

Alopecia: Clinical Cases

…ther manifestations of hyperandrogenism or virilization A skin biopsy is offered to the patient, which she accepts; she is highly-motivated to confirm the diagnosis of androgenetic alopecia; a 4 mm punch biopsy of the affected area of alopecia is per…

Therapeutic Strategies in Dermatology

Extramammary Paget’s/Paget’s Disease: Overview

…ut between 25% and 50% have an associated carcinoma. A careful lymph node evaluation is essential. Immunoperoxidase markers on paraffin fixed tissue can be used to identify the source of the primary carcinoma, or confirm that the lesion arose in the…

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